Salivary Exosomes in Health and Disease: Future Prospects in the Eye

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dc.creatorLiu, Angela
dc.creatorHefley, Brenna
dc.creatorEscandon, Paulina
dc.creatorNicholas, Sarah E.
dc.creatorKaramichos, Dimitrios
dc.creator.orcid0000-0002-8761-3824 (Karamichos, Dimitrios)
dc.date.accessioned2023-04-19T14:06:45Z
dc.date.available2023-04-19T14:06:45Z
dc.date.issued2023-04-14
dc.description.abstractExosomes are a group of vesicles that package and transport DNA, RNA, proteins, and lipids to recipient cells. They can be derived from blood, saliva, urine, and/or other biological tissues. Their impact on several diseases, such as neurodegenerative, autoimmune, and ocular diseases, have been reported, but not fully unraveled. The exosomes that are derived from saliva are less studied, but offer significant advantages over exosomes from other sources, due to their accessibility and ease of collection. Thus, their role in the pathophysiology of diseases is largely unknown. In the context of ocular diseases, salivary exosomes have been under-utilized, thus creating an enormous gap in the literature. The current review discusses the state of exosomes research on systemic and ocular diseases and highlights the role and potential of salivary exosomes as future ocular therapeutic vehicles.
dc.description.sponsorshipThe authors would like to acknowledge the following for their financial support: National Eye Institute, National Institutes of Health; (EY030028-04S1; D.K.).
dc.identifier.citationLiu, A., Hefley, B., Escandon, P., Nicholas, S. E., & Karamichos, D. (2023). Salivary Exosomes in Health and Disease: Future Prospects in the Eye. International journal of molecular sciences, 24(7), 6363. https://doi.org/10.3390/ijms24076363
dc.identifier.issn1422-0067
dc.identifier.issue7
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32344
dc.identifier.volume24
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/ijms24076363
dc.rights.holder© 2023 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciences
dc.subjectangiogenesis
dc.subjectbiomarker
dc.subjectexosomes
dc.subjectinflammatory cytokines
dc.subjectocular disease
dc.subjectsalivary exosomes
dc.subjectwound healing
dc.subject.meshExosomes / metabolism
dc.subject.meshSaliva / metabolism
dc.subject.meshProteins / metabolism
dc.subject.meshRNA / metabolism
dc.subject.meshEye
dc.titleSalivary Exosomes in Health and Disease: Future Prospects in the Eye
dc.typetext
dc.type.materialArticle

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