Effects of Acute Vaporized Nicotine in Non-Tobacco Users at Rest and during Exercise

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dc.creatorFogt, Donovan L.
dc.creatorLevi, Michael A.
dc.creatorRickards, Caroline A.
dc.creatorStelly, Steven P.
dc.creatorCooke, William H.
dc.creator.orcid0000-0002-5759-6912 (Rickards, Caroline A.)
dc.date.accessioned2022-11-21T19:47:07Z
dc.date.available2022-11-21T19:47:07Z
dc.date.issued2016-11-01
dc.description.abstractSmokers, and even non-smokers, may utilize vaporized nicotine delivered by electronic cigarette (EC) due to the perception that EC are "healthier" than traditional tobacco cigarettes. The effects of vaporized nicotine delivered by EC on resting blood pressure (BP) and resting metabolic rate (RMR), or BP and aerobic power during exercise have not been studied. This investigation tested the effects of acute vaporized nicotine inhalation by EC on resting BP and RMR and cycle exercise BP, metabolic responses, and aerobic power in young, normotensive non-smokers. Using a double-blind design, 20 subjects (10 female) participated in two randomized trials: placebo (0 mg nicotine) or nicotine (18 mg nicotine). Participants inhaled from EC once every 30 s for 10 min (20 inhalations total). RMR was assessed 40 min later by indirect calorimetry followed by an incremental cycle test. RMR was not different between trials (p=0.79). Compared to the placebo, resting diastolic pressure (DBP) was 3 mmHg higher with nicotine (p=0.04). VO2peak was not different between the nicotine trial (2.3+/-0.8 L*min(-1)) and placebo (2.3+/-0.7 L*min(-1)) trials (p=0.77), and Wmax was also similar between nicotine (201.0+/-53.8 W) and the placebo (204.8+/-57.8 W) (p=0.29). During the cycle exercise test, average DBP was higher following nicotine use compared with placebo trial (p=0.05), and exercise DBPpeak after nicotine (79.4+/-7.6) was significantly higher than placebo (74.9+/-8.3 mmHg) (p=0.02). Resting systolic blood pressure (SBP) was 3.7 mmHg lower for nicotine trial (p=0.04) but no SBP treatment effect was observed during exercise (p=0.14). Our results show that acute vaporized nicotine inhalation via EC increases resting and exercise DBP but does not affect RMR or cycle aerobic power in young, normotensive non-smokers.
dc.description.sponsorshipThis study was supported by a Collaborative Seed Grant through the Office of the Vice President for Research, University of Texas at San Antonio, San Antonio Texas.
dc.identifier.citationFogt, D. L., Levi, M. A., Rickards, C. A., Stelly, S. P., & Cooke, W. H. (2016). Effects of Acute Vaporized Nicotine in Non-Tobacco Users at Rest and during Exercise. International journal of exercise science, 9(5), 607-615.
dc.identifier.issn1939-795X
dc.identifier.issue5
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31954
dc.identifier.volume9
dc.publisherWestern Kentucky University
dc.relation.urihttps://digitalcommons.wku.edu/ijes/vol9/iss5/7
dc.rights.holder© The Author(s) 2016.
dc.rights.licenseAttribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.sourceInternational Journal of Exercise Science
dc.subjectnicotine
dc.subjectaerobic power
dc.subjectelectronic cigarettes
dc.subjectresting metabolism
dc.titleEffects of Acute Vaporized Nicotine in Non-Tobacco Users at Rest and during Exercise
dc.typeArticle
dc.type.materialtext

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