Evaluation of a Novel Multiplex Ministr System for Analysis of Degraded and Low Copy DNA Samples

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dc.contributor.advisorArthur Eisenberg
dc.contributor.committeeMemberJoseph Warren
dc.contributor.committeeMemberJohn Planz
dc.creatorOrcutt, Joseph L.
dc.date.accessioned2019-08-22T21:50:33Z
dc.date.available2019-08-22T21:50:33Z
dc.date.issued2006-05-01
dc.date.submitted2014-03-18T14:02:27-07:00
dc.description.abstractOrcutt, Joseph L., Evaluation of a Novel Multiplex MiniSTR System for Analysis of Degraded and Low Copy DNA Samples. Masters of Science (Forensic Genetics), May, 2006, 78 pp., 25 tables, 14 figures, bibliography, 20 titles. The goal was to evaluate the performance of a novel miniSTR multiplex system for the analysis of degraded and low quantity DNA samples. Three studies were designed to evaluate this new miniSTR kit: 1. A concordance study to insure that the profiles generated are identical to those with currently used STR kits; 2. A dilution study to identify the sensitivity limits of the multiplex system, and 3. The ability to generate profiles from DNA isolated from skeletal remains which had previously given incomplete profiles using conventional STR kits. The results indicate that the Applied Biosystems new miniSTR multiplex system will provide a valuable tool for forensic scientists to obtain genetic data from challenging casework samples.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29622
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCell and Developmental Biology
dc.subjectEquipment and Supplies
dc.subjectGenetic Processes
dc.subjectGenetics
dc.subjectGenetics and Genomics
dc.subjectHealth Information Technology
dc.subjectInvestigative Techniques
dc.subjectLife Sciences
dc.subjectMedical Genetics
dc.subjectMedicine and Health Sciences
dc.subjectMolecular Genetics
dc.subjectOther Genetics and Genomics
dc.subjectEvaluation
dc.subjectnovel multiplex MiniSTR System
dc.subjectAnalysis
dc.subjectDegraded and Low Copy DNA Samples
dc.subjectprofiles
dc.subjectSTR kits
dc.subjectdilution study
dc.subjectsensitivity limits
dc.subjectmultiplex system
dc.subjectskeletal remains
dc.subjectApplied BIosystems
dc.subjectforensic scientists
dc.subjectgenetic data
dc.subjectchallenging casework samples
dc.titleEvaluation of a Novel Multiplex Ministr System for Analysis of Degraded and Low Copy DNA Samples
dc.typeProfessional Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineForensic Genetics
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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