Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation

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dc.contributor.advisorShi, Xiangrong
dc.contributor.committeeMemberGwirtz, Patricia A.
dc.contributor.committeeMemberRaven, Peter B.
dc.creatorWray, David Walter
dc.date.accessioned2019-08-22T21:32:52Z
dc.date.available2019-08-22T21:32:52Z
dc.date.issued1999-12-01
dc.date.submitted2014-04-14T08:48:04-07:00
dc.description.abstractWray, David Walter, Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation. Master of Science (Biomedical Sciences), December, 1999, 70 pp., 7 tables, 8 illustrations, references, 83 titles. This study was designed to test the hypothesis that an age-related vagal dysfunction compromises arterial blood pressure (ABP) regulation. Changes in heart rate (HR) and ABP during lower body negative pressure (LBNP) were compared between ten elderly (≥60 yrs) and ten young (≤30 yrs) adults. A separate, young group (n=10) was also assessed following muscarinic cholinergic (MC) blockade with atropine (central and peripheral receptor blockade) or glycopyrrolate (peripheral receptor blockade) to simulate vagal dysfunction. During the onset of LBNP -40 too, orthostatic hypotension (OH) was observed in both the older subjects and the post-blockade younger subjects, with a diminished HR response. Furthermore, the reflex response to hypertensive stimuli was augmented in the post-blockade younger subjects, also associated with a diminution in HR response. We concluded that age-related or pharmacologically stimulated vagal dysfunction compromises ABP regulation during hypotensive and hypertensive stimuli, and that the difference between atropine and glycopyrrolate was insignificant.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29413
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectBiology
dc.subjectCardiovascular System
dc.subjectCirculatory and Respiratory Physiology
dc.subjectLife Sciences
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectPhysiology
dc.subjectPeripheral muscarinic cholinergic receptors
dc.subjectarterial blood pressure regulation
dc.subjectcentral muscarinic cholinergic receptors
dc.subjectABP
dc.subjectheart rate
dc.subjectlower body negative pressure
dc.subjectMC
dc.subjectatropine
dc.subjectglycopyrrolate
dc.subjectvagal dysfunction
dc.subjectreflex response
dc.titlePeripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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