Association of Magnesium Intake with Liver Fibrosis among Adults in the United States

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dc.creatorTao, Meng-Hua
dc.creatorFulda, Kimberly G.
dc.creator.orcid0000-0002-5096-2983 (Fulda, Kimberly G.)
dc.date.accessioned2022-06-30T14:29:35Z
dc.date.available2022-06-30T14:29:35Z
dc.date.issued2021-01-02
dc.description.abstractLiver fibrosis represents the consequences of chronic liver injury. Individuals with alcoholic or nonalcoholic liver diseases are at high risk of magnesium deficiency. This study aimed to evaluate the association between magnesium and calcium intakes and significant liver fibrosis, and whether the associations differ by alcohol drinking status. Based on the National Health and Nutrition Examination Survey (NHANES) 2017–2018, the study included 4166 participants aged >18 years who completed the transient elastography examination and had data available on magnesium intake. The median liver stiffness of 8.2 kPa was used to identify subjects with significant fibrosis (≥F2). The age-adjusted prevalence of significant fibrosis was 12.81%. Overall total magnesium intake was marginally associated with reduced odds of significant fibrosis (p trend = 0.14). The inverse association of total magnesium intake with significant fibrosis was primarily presented among those who had daily calcium intake <1200 mg. There were no clear associations for significant fibrosis with calcium intake. Findings suggest that high total magnesium alone may reduce risk of significant fibrosis. Further studies are needed to confirm these findings.
dc.description.sponsorshipTao's effort was partially supported by the National Institute on Minority Health and Health Disparities of the National Institute of Health under Award U54MD006882.
dc.identifier.citationTao, M. H., & Fulda, K. G. (2021). Association of Magnesium Intake with Liver Fibrosis among Adults in the United States. Nutrients, 13(1), 142. https://doi.org/10.3390/nu13010142
dc.identifier.issn2072-6643
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31242
dc.identifier.volume13
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/nu13010142
dc.rights.holderCopyright © 2021 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceNutrients
dc.subjectepidemiology
dc.subjectsignificant liver fibrosis
dc.subject.meshAdult
dc.subject.meshAlcohol Drinking
dc.subject.meshCalcium
dc.subject.meshEating
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLiver
dc.subject.meshLiver Cirrhosis
dc.subject.meshMagnesium
dc.subject.meshMagnesium Deficiency
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNutrition Surveys
dc.subject.meshNutritional Status
dc.subject.meshPrevalence
dc.subject.meshUnited States
dc.titleAssociation of Magnesium Intake with Liver Fibrosis among Adults in the United States
dc.typeArticle
dc.type.materialtext

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