Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

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dc.creatorKumar, Suneel
dc.creatorMathew, Stephen O.
dc.creatorAharwal, Ravindra P.
dc.creatorTulli, Hardeep S.
dc.creatorMohan, Chakrabhavi D.
dc.creatorSethi, Gautam
dc.creatorAhn, Kwang-Seok
dc.creatorWebber, Kassidy
dc.creatorSandhu, Sardul S.
dc.creatorBishayee, Anupam
dc.creator.orcid0000-0001-5784-224X (Mathew, Stephen O.)
dc.date.accessioned2023-03-27T15:24:24Z
dc.date.available2023-03-27T15:24:24Z
dc.date.issued2023-01-22
dc.description.abstractCancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer treatment. Unfortunately, these treatment options suffer from major limitations, such as drug-resistance and adverse effects, which may eventually result in disease recurrence. Many phytochemicals have been investigated for their antitumor efficacy in preclinical models and clinical studies to discover newer therapeutic agents with fewer adverse effects. Withaferin A, a natural bioactive molecule isolated from the Indian medicinal plant Withania somnifera (L.) Dunal, has been reported to impart anticancer activities against various cancer cell lines and preclinical cancer models by modulating the expression and activity of different oncogenic proteins. In this article, we have comprehensively discussed the biosynthesis of withaferin A as well as its antineoplastic activities and mode-of-action in in vitro and in vivo settings. We have also reviewed the effect of withaferin A on the expression of miRNAs, its combinational effect with other cytotoxic agents, withaferin A-based formulations, safety and toxicity profiles, and its clinical potential.
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) and the grant was funded by the Korean government (MSIP) (NRF-2021R1I1A2060024).
dc.identifier.citationKumar, S., Mathew, S. O., Aharwal, R. P., Tulli, H. S., Mohan, C. D., Sethi, G., Ahn, K.-S., Webber, K., Sandhu, S. S., & Bishayee, A. (2023). Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal. Pharmaceuticals, 16(2), 160. https://doi.org/10.3390/ph16020160
dc.identifier.issn1424-8247
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32063
dc.identifier.volume16
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/ph16020160
dc.rights.holder© 2023 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePharmaceuticals
dc.subjectwithaferin A
dc.subjectcancer
dc.subjectapoptosis
dc.subjectangiogenesis
dc.subjectchemoresistance
dc.subjectformulations
dc.titleWithaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
dc.typeArticle
dc.type.materialtext

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