Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair

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dc.creatorMcKay, Tina B.
dc.creatorEmmitte, Kyle A.
dc.creatorGerman, Carrie
dc.creatorKaramichos, Dimitrios
dc.creator.orcid0000-0002-8761-3824 (Karamichos, Dimitrios)
dc.creator.orcid0000-0002-6643-3947 (Emmitte, Kyle)
dc.date.accessioned2023-11-08T19:14:53Z
dc.date.available2023-11-08T19:14:53Z
dc.date.issued2023-10-28
dc.description.abstractQuercetin is a polyphenol of the flavonoid class of secondary metabolites that is widely distributed in the plant kingdom. Quercetin has been found to exhibit potent bioactivity in the areas of wound healing, neuroprotection, and anti-aging research. Naturally found in highly glycosylated forms, aglycone quercetin has low solubility in aqueous environments, which has heavily limited its clinical applications. To improve the stability and bioavailability of quercetin, efforts have been made to chemically modify quercetin and related flavonoids so as to improve aqueous solubility while retaining bioactivity. In this review, we provide an updated overview of the biological properties of quercetin and proposed mechanisms of actions in the context of wound healing and aging. We also provide a description of recent developments in synthetic approaches to improve the solubility and stability of quercetin and related analogs for therapeutic applications. Further research in these areas is expected to enable translational applications to improve ocular wound healing and tissue repair.
dc.description.sponsorshipThis study was funded by the National Institutes of Health/National Eye Institute grant R01EY028888 (DK).
dc.identifier.citationMcKay, T. B., Emmitte, K. A., German, C., & Karamichos, D. (2023). Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair. Bioengineering (Basel, Switzerland), 10(10), 1127. https://doi.org/10.3390/bioengineering10101127
dc.identifier.issn2306-5354
dc.identifier.issue10
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32439
dc.identifier.volume10
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/bioengineering10101127
dc.rights.holder© 2023 by the authors.
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceBioengineering (Basel)
dc.subjectaging
dc.subjectcornea
dc.subjectfibrosis
dc.subjectflavonoids
dc.subjectkaempferol
dc.subjectmyricetin
dc.subjectneuroprotective
dc.subjectquercetin
dc.subjectwound healing
dc.titleQuercetin and Related Analogs as Therapeutics to Promote Tissue Repair
dc.typeArticle
dc.type.materialtext

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