Effect of creatine on nociception in a mouse model of inflammatory pain

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dc.contributor.advisorSumien, Nathalie
dc.contributor.committeeMemberGonzales, Eric B.
dc.contributor.committeeMemberGatch, Michael B.
dc.creatorIzurieta Munoz, Haydee S.
dc.date.accessioned2019-08-22T21:01:01Z
dc.date.available2019-08-22T21:01:01Z
dc.date.issued2015-05-01
dc.date.submitted2016-08-05T14:18:05-07:00
dc.description.abstractThe objective of this study was to evaluate creatine as an anti-nociceptive compound in an animal model of thermal and inflammatory pain. Creatine has the structural potential to interact with acid-sensing ion channel 3 (ASIC3), which have been involved in pain sensation modulation. Our hypothesis was that creatine will interact with ASIC3 leading to decreased nociception. Male and female C57BL/6J mice were supplemented with creatine (6.25g/kg diet) and tested for thermal hyperalgesia and inflammatory pain response. The latency to withdraw the tail during the thermal hyperalgesia test was unaffected by sex or diet. For the formalin test, males and females responded differently to the stimulus, and the female mice supplemented with creatine seemed to recover faster than the controls. These preliminary data suggest a potential effect of creatine and sex on inflammation-based nociception and can be used as a stepping stone for the development of ASIC-based therapeutics
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29000
dc.language.isoen
dc.provenance.legacyDownloads52
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectnociception
dc.subjectpain
dc.subjectacid sensing ion channels
dc.subjectASIC3
dc.subjectinflammatory pain
dc.titleEffect of creatine on nociception in a mouse model of inflammatory pain
dc.typeInternship Practicum Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiotechnology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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