The Effectiveness of Outpatient Antiemetic for Patients on Platinum, Camptosar, and Anthracycline-Based Chemotherapy

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dc.contributor.advisorVictoria Rudick
dc.contributor.committeeMemberJulie Prejean
dc.creatorWiggins, Jenny Marie
dc.date.accessioned2019-08-22T19:51:25Z
dc.date.available2019-08-22T19:51:25Z
dc.date.issued2002-07-25
dc.date.submitted2014-04-14T08:48:04-07:00
dc.description.abstractAbstract. Chemotherapy-induced nausea and vomiting (CINV) is a serious problem affecting at least 50% of patients. Some nausea and vomit pathways involve serotonin and serotonin type-3 (5-HT3) receptors for propagation of the reflex. 5-HT3 antagonists were developed to block the 5-HT3 receptors and inhibit emesis. Anzemet, Kytril, and Zofran are 5-HT3 antagonists used as antiemetics in patients receiving emetogenic chemotherapy. This study was designed to determine if current antiemetic therapy involving these 5-HT3 antagonists is effective for patents on platinum, camptosar, and anthracycline-based chemotherapy. The data from this study could be used to assert or adjust antiemetic therapy in patients on these chemotherapy regimens, thus providing better quality of life for patients as they undergo chemotherapy. Patients on platinum, camptosar, or anthracycline-based chemotherapies from three Fort Worth area clinics of Texas Cancer Care were chosen to gauge the effectiveness of their antiemetic regimen based on chemotherapy regimen, patient compliance, and specific 5-HT3 antagonist. Data was gathered based on questionnaires filled out by the patient for seven days and their chemotherapy nurse on the day of their treatment. It was found that Zofran was the 5-HT3 antagonist most often prescribed by the nurses. Patient compliance was not a factor in patient perception of CINV, because of the high levels of patient cooperation. Each of the chemotherapy regimens differed by day in overall average level of CINV. Patients on Kytril were found to experience more “severe” CINV than those taking Anzemet or those not taking a 5-HT3 antagonist as an outpatient. A recommendation from this study would be a larger sample size and a larger span of time. Each of the study sites should also be compared for nurse prescribing habits and patient compliance, as well as a higher level of decadron usage for patients experiencing moderate and severe CINV.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/27114
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCancer Biology
dc.subjectChemical Actions and Uses
dc.subjectChemicals and Drugs
dc.subjectClinical Epidemiology
dc.subjectDiseases
dc.subjectHealth and Medical Administration
dc.subjectHealth Services Research
dc.subjectLife Sciences
dc.subjectMedical Pharmacology
dc.subjectMedical Sciences
dc.subjectMedical Toxicology
dc.subjectMedicine and Health Sciences
dc.subjectNursing
dc.subjectOncology
dc.subjectOther Chemicals and Drugs
dc.subjectOther Nursing
dc.subjectOther Pharmacy and Pharmaceutical Sciences
dc.subjectPharmaceutical Preparations
dc.subjectPharmacy and Pharmaceutical Sciences
dc.subjectPublic Health
dc.subjectChemotherapy-induced nausea and vomiting
dc.subjectCINV
dc.subjectnausea
dc.subjectvomit pathways
dc.subjectserotonin
dc.subject5-HT3 receptors
dc.subjectserotonin type-3
dc.subjectantiemetics
dc.subjectemetogenic chemotherapy
dc.subjectZofran
dc.subjectprescription
dc.subjectchemo
dc.subjectchemotherapy regimen
dc.subjectKytril
dc.subjectAnzemet
dc.subjectnurse
dc.subjectdecadron usage
dc.titleThe Effectiveness of Outpatient Antiemetic for Patients on Platinum, Camptosar, and Anthracycline-Based Chemotherapy
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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