The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics

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dc.creatorO'Bryant, Sid E.
dc.creatorJohnson, Leigh A.
dc.creatorBarber, Robert C.
dc.creatorBraskie, Meredith N.
dc.creatorChristian, Bradley
dc.creatorHall, James R.
dc.creatorHazra, Nalini
dc.creatorKing, Kevin
dc.creatorKothapalli, Deydeep
dc.creatorLarge, Stephanie
dc.creatorMason, David
dc.creatorMatsiyevskiy, Elizabeth
dc.creatorMcColl, Roderick
dc.creatorNandy, Rajesh
dc.creatorPalmer, Raymond
dc.creatorPetersen, Melissa E.
dc.creatorPhilips, Nicole
dc.creatorRissman, Robert A.
dc.creatorShi, Yonggang
dc.creatorToga, Arthur W.
dc.creatorVintimilla, Raul
dc.creatorVig, Rocky
dc.creatorZhang, Fan
dc.creatorYaffe, Kristine
dc.creator.orcid0000-0001-6857-0286 (Barber, Robert C.)
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.creator.orcid0000-0002-3920-5877 (Petersen, Melissa E.)
dc.creator.orcid0000-0002-4176-0001 (Vintimilla, Raul)
dc.date.accessioned2022-06-29T17:06:29Z
dc.date.available2022-06-29T17:06:29Z
dc.date.issued2021-06-21
dc.description.abstractIntroduction: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. Methods: Community-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository. Results: Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites. Discussion: The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.
dc.description.sponsorshipResearch reported here was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073 and R01AG058533. This work was also supported in part by NIH/National Institute of Biomedical Imaging and Bioengineering award P41-EB015992.
dc.identifier.citationO'Bryant, S. E., Johnson, L. A., Barber, R. C., Braskie, M. N., Christian, B., Hall, J. R., Hazra, N., King, K., Kothapalli, D., Large, S., Mason, D., Matsiyevskiy, E., McColl, R., Nandy, R., Palmer, R., Petersen, M., Philips, N., Rissman, R. A., Shi, Y., Toga, A. W., ... HABLE Study Team (2021). The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics. Alzheimer's & dementia (Amsterdam, Netherlands), 13(1), e12202. https://doi.org/10.1002/dad2.12202
dc.identifier.issn2352-8729
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31211
dc.identifier.volume13
dc.publisherWiley Periodicals, LLC
dc.relation.urihttps://doi.org/10.1002/dad2.12202
dc.rights.holderCopyright © 2021 The Authors.
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAlzheimer's & Dementia: Translational Research & Clinical Interventions
dc.subjectAlzheimer's disease
dc.subjectHispanic
dc.subjectdiversity
dc.subjectmild cognitive impairment
dc.subjectneurodegeneration
dc.subject.meshAlzheimer Disease
dc.subject.meshCognitive Dysfunction
dc.subject.meshMexican Americans
dc.subject.meshAmyloid
dc.subject.meshBiomarkers
dc.titleThe Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics
dc.typeArticle
dc.type.materialtext

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