Allostery: An Overview of Its History, Concepts, Methods, and Applications

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dc.creatorLiu, Jin
dc.creatorNussinov, Ruth
dc.creator.orcid0000-0002-1067-4063 (Liu, Jin)
dc.date.accessioned2022-09-30T17:34:18Z
dc.date.available2022-09-30T17:34:18Z
dc.date.issued2016-06-02
dc.description.abstractThe concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904) to the birth of allostery by Monod and Jacob (1961). We describe the evolution of the allostery concept, from a conformational change in a two-state model (1965, 1966) to dynamic allostery in the ensemble model (1999); from multi-subunit (1965) proteins to all proteins (2004). We highlight the current available methods to study allostery and their applications in studies of conformational mechanisms, disease, and allosteric drug discovery. We outline the challenges and future directions that we foresee. Altogether, this Editorial narrates the history of this fundamental concept in the life sciences, its significance, methodologies to detect and predict it, and its application in a broad range of living systems.
dc.description.sponsorshipThe authors received no specific funding for this article.
dc.identifier.citationLiu, J., & Nussinov, R. (2016). Allostery: An Overview of Its History, Concepts, Methods, and Applications. PLoS computational biology, 12(6), e1004966. https://doi.org/10.1371/journal.pcbi.1004966
dc.identifier.issn1553-7358
dc.identifier.issue6
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31821
dc.identifier.volume12
dc.publisherPLOS
dc.relation.urihttps://doi.org/10.1371/journal.pcbi.1004966
dc.rights.holder© 2016 Liu, Nussinov.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePLoS Computational Biology
dc.subject.meshAllosteric Regulation
dc.subject.meshBiochemistry / history
dc.subject.meshBiomedical Research / history
dc.subject.meshHistory, 20th Century
dc.subject.meshHistory, 21st Century
dc.subject.meshHumans
dc.subject.meshModels, Biological
dc.titleAllostery: An Overview of Its History, Concepts, Methods, and Applications
dc.typeArticle
dc.type.materialtext

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