Current state of Alzheimer's fluid biomarkers

Simple item page
dc.creatorMolinuevo, José Luis
dc.creatorAyton, Scott
dc.creatorBatrla, Richard
dc.creatorBednar, Martin M.
dc.creatorBittner, Tobias
dc.creatorCummings, Jeffrey
dc.creatorFagan, Anne M.
dc.creatorHampel, Harald
dc.creatorMielke, Michelle M.
dc.creatorMikulskis, Alvydas
dc.creatorO'Bryant, Sid E.
dc.creatorScheltens, Philip
dc.creatorSevigny, Jeffrey
dc.creatorShaw, Leslie M.
dc.creatorSoares, Holly D.
dc.creatorTong, Gary
dc.creatorTrojanowski, John Q.
dc.creatorZetterberg, Henrik
dc.creatorBlennow, Kaj
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.date.accessioned2022-07-07T13:54:26Z
dc.date.available2022-07-07T13:54:26Z
dc.date.issued2018-11-28
dc.description.abstractAlzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is predicted to increase; however, there are no disease-modifying therapies currently available and none have been successful in late-stage clinical trials. Fluid biomarkers measured in cerebrospinal fluid (CSF) or blood hold promise for enabling more effective drug development and establishing a more personalized medicine approach for AD diagnosis and treatment. Biomarkers used in drug development programmes should be qualified for a specific context of use (COU). These COUs include, but are not limited to, subject/patient selection, assessment of disease state and/or prognosis, assessment of mechanism of action, dose optimization, drug response monitoring, efficacy maximization, and toxicity/adverse reactions identification and minimization. The core AD CSF biomarkers Aβ42, t-tau, and p-tau are recognized by research guidelines for their diagnostic utility and are being considered for qualification for subject selection in clinical trials. However, there is a need to better understand their potential for other COUs, as well as identify additional fluid biomarkers reflecting other aspects of AD pathophysiology. Several novel fluid biomarkers have been proposed, but their role in AD pathology and their use as AD biomarkers have yet to be validated. In this review, we summarize some of the pathological mechanisms implicated in the sporadic AD and highlight the data for several established and novel fluid biomarkers (including BACE1, TREM2, YKL-40, IP-10, neurogranin, SNAP-25, synaptotagmin, ɑ-synuclein, TDP-43, ferritin, VILIP-1, and NF-L) associated with each mechanism. We discuss the potential COUs for each biomarker.
dc.description.sponsorshipThe research leading to these results has received funding from the program "Investissements d'avenir" ANR-10-IAIHU-06 (Agence Nationale de la Recherche-10-IA Agence Institut Hospitalo-Universitaire-6).
dc.identifier.citationMolinuevo, J. L., Ayton, S., Batrla, R., Bednar, M. M., Bittner, T., Cummings, J., Fagan, A. M., Hampel, H., Mielke, M. M., Mikulskis, A., O'Bryant, S., Scheltens, P., Sevigny, J., Shaw, L. M., Soares, H. D., Tong, G., Trojanowski, J. Q., Zetterberg, H., & Blennow, K. (2018). Current state of Alzheimer's fluid biomarkers. Acta neuropathologica, 136(6), 821-853. https://doi.org/10.1007/s00401-018-1932-x
dc.identifier.issn1432-0533
dc.identifier.issue6
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31534
dc.identifier.volume136
dc.publisherSpringer
dc.relation.urihttps://doi.org/10.1007/s00401-018-1932-x
dc.rights.holderCopyright © The Author(s) 2018
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceActa Neuropathologica
dc.subjectAlzheimer's disease
dc.subjectTau
dc.subject.meshAlzheimer Disease
dc.subject.meshBiomarkers
dc.subject.meshHumans
dc.subject.meshAmyloid
dc.subject.meshCerebrospinal Fluid
dc.titleCurrent state of Alzheimer's fluid biomarkers
dc.typeArticle
dc.type.materialtext

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1007_s00401-018-1932-x.pdf
Size:
1.92 MB
Format:
Adobe Portable Document Format
Description:
full text article
Download

Collections

Publications -- Sid E. O'Bryant