Effects of the Pleiotropic Gene csrA on Glycogen Metabolism in Escherichia Coli

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dc.contributor.advisorMing-Chi Wu
dc.contributor.committeeMemberWayne Nicholson
dc.creatorYang, Honghui
dc.date.accessioned2019-08-22T21:01:33Z
dc.date.available2019-08-22T21:01:33Z
dc.date.issued1995-06-01
dc.date.submitted2014-04-14T08:48:04-07:00
dc.description.abstractYang, Honghui, Effects of the pleiotropic gene csrA on glycogen metabolism in Escherichia coli. Master of Science (Biomedical Sciences), June, 1995, 78 pp., 3 tables, 17 illustrations, bibliography, 59 titles. The csrA gene negatively regulates the expression of four genes glgB, glgC, glgA and glgS involved in glycogen synthesis. It also negatively regulates glgY, which encodes the enzyme glycogen phoshorylase involved in glycogen degradation, but no effect was observed on the glycogen debranching enzyme in this pathway. In addition, csrA exhibits a positive effect on the glycolytic enzyme triosephosphate isomerase. No significant effects were observed on the expression of two genes (zwf & gnd) participating in the pentose phosphate pathway. In vitro expression of glgB, glgC and glgA was specifically inhibited by cell extracts containing the csrA gene product (CsrA). This study provides evidence that csrA encodes an important regulator of intermediary carbon metabolism in Escherichia coli.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29008
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectBacteria
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectDevelopmental Biology
dc.subjectGenetics
dc.subjectGenetics and Genomics
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedical Genetics
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectOther Cell and Developmental Biology
dc.subjectOther Genetics and Genomics
dc.subjectPleiotropic gene
dc.subjectcsrA
dc.subjectglycogen metabolism
dc.subjectEscherichia coli
dc.subjectgene expression
dc.subjectglycogen synthesis
dc.subjecttriosephosphate isomerase
dc.subjectE. coli
dc.titleEffects of the Pleiotropic Gene csrA on Glycogen Metabolism in Escherichia Coli
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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