MRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort

Simple item page
dc.creatorVintimilla, Raul
dc.creatorHall, James R.
dc.creatorKing, Kevin
dc.creatorBraskie, Meredith N.
dc.creatorJohnson, Leigh A.
dc.creatorYaffe, Kristine
dc.creatorToga, Arthur W.
dc.creatorO'Bryant, Sid E.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.creator.orcid0000-0002-4176-0001 (Vintimilla, Raul)
dc.date.accessioned2022-07-07T13:54:27Z
dc.date.available2022-07-07T13:54:27Z
dc.date.issued2021-10-14
dc.description.abstractBackground: The current project sought to evaluate the impact that white matter hyperintensities (WMH) have on executive function in cognitively normal Mexican Americans, an underserved population with onset and more rapid progression of dementia. Methods: Data from 515 participants (360 female) enrolled in the Health and Aging Brain Study: Health Disparities project were analyzed. Participants underwent clinical evaluation, cognitive testing, and a brain MRI. Linear regression was used to predict the effect of total WMH volume on cognitive test scores. Age, sex, and education were entered as covariates. Results: Regression analysis showed that WMH volume significantly predicted executive function. WMH also predicted global cognition and attention scores, although not significantly after adjusting for age. Conclusion: In this sample of cognitively normal Mexican Americans, we found that WMH volume was associated with lower scores in a measure of executive function, after accounting for age, sex, and education.
dc.identifier.citationVintimilla, R., Hall, J., King, K., Braskie, M. N., Johnson, L., Yaffe, K., Toga, A. W., O'Bryant, S., & Health and Aging Brain Study (HABS-HD) Study Team (2021). MRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort. Alzheimer's & dementia (Amsterdam, Netherlands), 13(1), e12236. https://doi.org/10.1002/dad2.12236
dc.identifier.issn2352-8729
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31544
dc.identifier.volume13
dc.publisherWiley Periodicals, LLC
dc.relation.urihttps://doi.org/10.1002/dad2.12236
dc.rights.holderCopyright © 2021 The Authors.
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAlzheimer's & Dementia Diagnosis, Assessment & Disease Monitoring
dc.subjectcardiovascular risk factors
dc.subjectcerebral small vessel disease
dc.subjectcognition
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshHeart Disease Risk Factors
dc.subject.meshMexican Americans
dc.titleMRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort
dc.typeArticle
dc.type.materialtext

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1002_dad2.12236.pdf
Size:
210.91 KB
Format:
Adobe Portable Document Format
Description:
full text article
Download

Collections

Publications -- Sid E. O'Bryant
Publications -- James R. Hall
Publications -- Leigh A. Johnson