Rat Strain and Housing Conditions Alter Oxidative Stress and Hormone Responses to Chronic Intermittent Hypoxia

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dc.creatorSnyder, Brina D.
dc.creatorDuong, Phong
dc.creatorTenkorang, Mavis A. A.
dc.creatorWilson, E. Nicole
dc.creatorCunningham, Rebecca L.
dc.creator.orcid0000-0001-5984-5516 (Cunningham, Rebecca)
dc.creator.orcid0000-0001-6254-4941 (Snyder, Brina D.)
dc.date.accessioned2022-09-06T14:39:00Z
dc.date.available2022-09-06T14:39:00Z
dc.date.issued2018-11-06
dc.description.abstractSleep apnea has been associated with elevated risk for metabolic, cognitive, and cardiovascular disorders. Further, the role of hypothalamic-pituitary-adrenal (HPA) activation in sleep apnea has been controversial in human studies. Chronic intermittent hypoxia (CIH) is a rodent model, which mimics the hypoxemia experienced by patients with sleep apnea. Most studies of CIH in rats have been conducted in the Sprague Dawley rat strain. Previously published literature suggests different strains of rats exhibit various responses to disease models, and these effects can be further modulated by the housing conditions experienced by each strain. This variability in response is similar to what has been observed in clinical populations, especially with respect to the HPA system. To investigate if strain or housing (individual or pair-housed) can affect the results of CIH (AHI 8 or 10) treatment, we exposed individual and pair-housed Sprague Dawley and Long-Evans male rats to 7 days of CIH treatment. This was followed by biochemical analysis of circulating hormones, oxidative stress, and neurodegenerative markers. Both strain and housing conditions altered oxidative stress generation, hyperphosphorylated tau protein (tau tangles), circulating corticosterone and adrenocorticotropic hormone (ACTH), and weight metrics. Specifically, pair-housed Long-Evans rats were the most sensitive to CIH, which showed a significant association between oxidative stress generation and HPA activation under conditions of AHI of 8. These results suggest both strain and housing conditions can affect the outcomes of CIH.
dc.description.sponsorshipThis work was supported by the NIH under grant R01 NS091359 and The Alzheimer's Association New Investigator Research Grant NIRG-14-321722 to RC and by a NIH training grant T32 AG 020494 to BS.
dc.identifier.citationSnyder, B., Duong, P., Tenkorang, M., Wilson, E. N., & Cunningham, R. L. (2018). Rat Strain and Housing Conditions Alter Oxidative Stress and Hormone Responses to Chronic Intermittent Hypoxia. Frontiers in physiology, 9, 1554. https://doi.org/10.3389/fphys.2018.01554
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31666
dc.identifier.volume9
dc.publisherFrontiers Media S.A.
dc.relation.urihttps://doi.org/10.3389/fphys.2018.01554
dc.rights.holderCopyright © 2018 Snyder, Duong, Tenkorang, Wilson and Cunningham.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Physiology
dc.subjectActh
dc.subjectcorticosterone
dc.subjecthyperphosphorylated tau
dc.subjecthypothalamic-pituitary-adrenal axis
dc.subjectoxidative stress
dc.subjectreproducibility
dc.titleRat Strain and Housing Conditions Alter Oxidative Stress and Hormone Responses to Chronic Intermittent Hypoxia
dc.typeArticle
dc.type.materialtext

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