Polymorphism of Y-STR haplotypes is governed by patrilineal ancestry combined with effects of male migration

Simple item page
dc.contributor.advisorRanajit Chakraborty
dc.contributor.committeeMemberJohn V. Planz
dc.creatorNolan, Michael R.
dc.date.accessioned2019-08-22T21:07:28Z
dc.date.available2019-08-22T21:07:28Z
dc.date.issued2015-12-01
dc.date.submitted2016-01-07T09:06:06-08:00
dc.description.abstractThis study examined geographic origins of Y-haplogroups and effects of migration using Y-STR haplotype databases compiled from the literature. Accuracy of haplogroup prediction was analyzed by varying the number of loci in haplotype definitions and by including rapidly mutating Y-STRs. Lastly, haplogroup diversities of populations were analyzed with respect to evolutionary history/size of populations and effects of admixture. These analyses demonstrated: a) haplotype definitions with more loci increased haplogroup prediction accuracy; b) older populations did not negatively impact haplogroup prediction; c) including rapidly mutating loci as part of the haplotype-definition had minimal impact on haplogroup prediction and inferring population clustering, but had moderate impact on Network analysis; and d) haplogroup diversities increased with male admixture.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29088
dc.language.isoen
dc.provenance.legacyDownloads20
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectY-STR
dc.subjecthaplotype
dc.subjectmale migration
dc.subjectpatrilineal ancestry
dc.titlePolymorphism of Y-STR haplotypes is governed by patrilineal ancestry combined with effects of male migration
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2015_12_gsbs_Nolan_Michael_thesis.pdf
Size:
969.5 KB
Format:
Adobe Portable Document Format
Download

Collections

School of Biomedical Sciences
Theses and Dissertations