Detection of Androgen Receptors by Flow Cytometry

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dc.contributor.advisorMcClain, Robert
dc.contributor.committeeMemberSingh, Meharvan
dc.contributor.committeeMemberHall, Stan
dc.creatorDutta, Mayurika
dc.date.accessioned2019-08-22T21:03:00Z
dc.date.available2019-08-22T21:03:00Z
dc.date.issued2008-05-01
dc.date.submitted2014-05-05T12:18:05-07:00
dc.description.abstractDutta, Mayurika, ‘Detection of androgen receptors by Flow Cytometry’. Internship Practicum report, Biotechnology, May 2008, 80 pp., 1 table, 18 figures. The use of androgen therapy is expanding given the documented potential benefits like increasing bone mineral density, muscle mass and strength. Androgen therapy also has potential risks including increasing the likelihood of prostate cancer and cardiovascular disease. So, we need a way to differentiate those who are likely to be benefitted by the therapy and those that are not. Data from Dr. Meharvan Singh’s lab has shown that activation of intracellular androgen receptors triggers cell survival pathways, while activation of the membrane androgen receptor suppresses cytoprotective pathways, and thus promotes cell death. We propose to develop a diagnostic kit that measures the relative ratio of intracellular androgen receptors and membrane androgen receptors, which is predicted to gauge relative risks or benefits associated with androgen therapy.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29028
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCancer Biology
dc.subjectCardiovascular Diseases
dc.subjectCardiovascular System
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectDevelopmental Biology
dc.subjectLaboratory and Basic Science Research
dc.subjectLife Sciences
dc.subjectMale Urogenital Diseases
dc.subjectMedical Cell Biology
dc.subjectMedicine and Health Sciences
dc.subjectOther Cell and Developmental Biology
dc.subjectUrogenital System
dc.subjectDetection
dc.subjectandrogen receptors
dc.subjectflow cytometry
dc.subjectinternship practicum report
dc.subjectandrogen therapy
dc.subjectprostate cancer
dc.subjectcardiovascular disease
dc.subjectcytoprotective pathways
dc.subjectcell death
dc.subjectcell survival pathways
dc.titleDetection of Androgen Receptors by Flow Cytometry
dc.typeProfessional Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiotechnology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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