Effects of Testosterone on Obesity-Related Cardiac Hypertrophy and Fibrosis

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dc.contributor.advisorJoan F. Carroll
dc.contributor.committeeMemberJames L. Caffrey
dc.contributor.committeeMemberRobert T. Mallet
dc.creatorWilson, Ana Kaye
dc.date.accessioned2019-08-22T21:27:58Z
dc.date.available2019-08-22T21:27:58Z
dc.date.issued2009-08-01
dc.date.submitted2014-04-14T08:48:04-07:00
dc.description.abstractWilson, Ana Kaye. Effects of testosterone on obesity-related cardiac hypertrophy and fibrosis. Master of Science (Integrative Physiology), August 2009, 71 pp, 3 tables, 6 figures. Both testosterone and obesity are known to increase renin-angiotensin system activity, leading to cardiovascular dysfunction. This study determined the interactive effects of obesity and testosterone on left ventricular hypertrophy and cardiac fibrotic factors. Male New Zealand White rabbits were fed a lean or 10% added fat diet. After 12 weeks, fat-fed rabbits exhibited increased left ventricular weight (6.05±0.16 vs. 4.75±0.10 g, respectively, p≤0.05) and cardiomyocyte cross-sectional area compared to lean rabbits (372.3±19.0 vs. 305.0±13.4μm2, respectively; p≤0.01). These effects were attenuated by both castration and treatment with the angiotensin type 1 receptor blocker, losartan. Obese rabbits did not exhibit increased myocardial collagen as expected. However, castration and losartan treatment increased matrix metalloproteinase-2 (MMP-2) activity in obese rabbits. Despite the effects of castration hypertrophy and MMP-2 activity, castration did not attenuate plasma renin activity of aldosterone. These data suggest that testosterone contributes to obesity-related left ventricular hypertrophy and decreases collagen degradation, independent of renin activity.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29353
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectAnimal Sciences
dc.subjectBiology
dc.subjectCardiovascular System
dc.subjectChemicals and Drugs
dc.subjectComparative and Laboratory Animal Medicine
dc.subjectLife Sciences
dc.subjectMedical Physiology
dc.subjectMedicine and Health Sciences
dc.subjectNutrition
dc.subjectOther Animal Sciences
dc.subjectOther Nutrition
dc.subjectPhysiology
dc.subjectSystems and Integrative Physiology
dc.subjectVeterinary Medicine
dc.subjectEffects
dc.subjecttestosterone
dc.subjectobesity-related
dc.subjectcardiac hypertrophy
dc.subjectfibrosis
dc.subjectobesity
dc.subjectrenin-angiotensin
dc.subjectleft ventricular hypertrophy
dc.subjectcardiac fibrotic factors
dc.subjectMale New Zealand White rabbits
dc.subjectfat diet
dc.subjectlean rabbits
dc.subjectcastration
dc.subjectangiotensin type 1 receptor blocker
dc.subjectlosartan
dc.subjectmatrix metalloproteinase-2
dc.subjectMMP-2
dc.subjectcastration hypertrophy
dc.subjectaldosterone
dc.subjectcollagen degradation
dc.subjectrenin activity
dc.titleEffects of Testosterone on Obesity-Related Cardiac Hypertrophy and Fibrosis
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineIntegrative Physiology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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