QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis

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dc.creatorLiu, Hailing
dc.creatorHuang, Zifeng
dc.creatorDeng, Bin
dc.creatorChang, Zihan
dc.creatorYang, Xiaohua
dc.creatorGuo, Xinfang
dc.creatorYuan, Feilan
dc.creatorYang, Qin
dc.creatorWang, Liming
dc.creatorZou, Haiqiang
dc.creatorLi, Mengyan
dc.creatorZhu, Zhaohua
dc.creatorJin, Kunlin
dc.creatorWang, Qing
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.date.accessioned2023-03-27T15:24:23Z
dc.date.available2023-03-27T15:24:23Z
dc.date.issued2023-02-24
dc.description.abstractParkinson's disease (PD) and atypical parkinsonism (AP), including progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), share similar nonmotor symptoms. Quantitative electroencephalography (QEEG) can be used to examine the nonmotor symptoms. This study aimed to characterize the patterns of QEEG and functional connectivity (FC) that differentiate PD from PSP or MSA, and explore the correlation between the differential QEEG indices and nonmotor dysfunctions in PD and AP. We enrolled 52 patients with PD, 31 with MSA, 22 with PSP, and 50 age-matched health controls to compare QEEG indices among specific brain regions. One-way analysis of variance was applied to assess QEEG indices between groups; Spearman's correlations were used to examine the relationship between QEEG indices and nonmotor symptoms scale (NMSS) and mini-mental state examination (MMSE). FCs using weighted phase lag index were compared between patients with PD and those with MSA/PSP. Patients with PSP revealed higher scores on the NMSS and lower MMSE scores than those with PD and MSA, with similar disease duration. The delta and theta powers revealed a significant increase in PSP, followed by PD and MSA. Patients with PD presented a significantly lower slow-to-fast ratio than those with PSP in the frontal region, while patients with PD presented significantly higher EEG-slowing indices than patients with MSA. The frontal slow-to-fast ratio showed a negative correlation with MMSE scores in patients with PD and PSP, and a positive correlation with NMSS in the perception and mood domain in patients with PSP but not in those with PD. Compared to PD, MSA presented enhanced FC in theta and delta bands in the posterior region, while PSP revealed decreased FC in the delta band within the frontal-temporal cortex. These findings suggest that QEEG might be a useful tool for evaluating the nonmotor dysfunctions in PD and AP. Our QEEG results suggested that with similar disease duration, the cortical neurodegenerative process was likely exacerbated in patients with PSP, followed by those with PD, and lastly in patients with MSA.
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (NO: 81873777, 82071414), Initiated Foundation of Zhujiang Hospital (NO: 02020318005), Natural Science Foundation of Guangdong of China (NO: 2017A030311010) and Science and Technology Program of Guangdong of China (NO: 2020A0505100037) to Q.W; and the High-level Hospital Construction Research Project of Maoming People's Hospital (NO: xz2020009) and Science and Technology Program of Maoming City (NO: 2021S0026) to H.L.L.
dc.identifier.citationLiu, H., Huang, Z., Deng, B., Chang, Z., Yang, X., Guo, X., Yuan, F., Yang, Q., Wang, L., Zou, H., Li, M., Zhu, Z., Jin, K., & Wang, Q. (2023). QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis. Aging and disease, 14(1), 204-218. https://doi.org/10.14336/AD.2022.0514
dc.identifier.issn2152-5250
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32059
dc.identifier.volume14
dc.publisherAging and Disease
dc.relation.urihttps://doi.org/10.14336/AD.2022.0514
dc.rights.holder© 2022 Liu H. et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectParkinson's disease
dc.subjectatypical parkinsonism
dc.subjectfunctional connectivity
dc.subjectmultiple system atrophy
dc.subjectprogressive supranuclear palsy
dc.subjectquantitative electroencephalography
dc.titleQEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis
dc.typeArticle
dc.type.materialtext

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