Ubiquitin-protein ligase E3A (UBE3A) mediation of viral infection and human diseases

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dc.creatorChaudhary, Pankaj
dc.creatorProulx, Jessica
dc.creatorPark, In-Woo
dc.creator.orcid0000-0003-0518-4120 (Chaudhary, Pankaj)
dc.date.accessioned2023-08-10T14:45:31Z
dc.date.available2023-08-10T14:45:31Z
dc.date.issued2023-08-05
dc.description.abstractThe Ubiquitin-protein ligase E3A, UBE3A, also known as E6-associated protein (E6-AP), is known to play an essential role in regulating the degradation of various proteins by transferring Ub from E2 Ub conjugating enzymes to the substrate proteins. Several studies indicate that UBE3A regulates the stabilities of key viral proteins in the virus-infected cells and, thereby, the infected virus-mediated diseases, even if it were reported that UBE3A participates in non-viral-related human diseases. Furthermore, mutations such as deletions and duplications in the maternally inherited gene in the brain cause human neurodevelopmental disorders such as Angelman syndrome (AS) and autism. It is also known that UBE3A functions as a transcriptional coactivator for the expression of steroid hormone receptors. These reports establish that UBE3A is distinguished by its multitudinous functions that are paramount to viral pathology and human diseases. This review is focused on molecular mechanisms for such intensive participation of UBE3A in disease formation and virus regulation.
dc.description.sponsorshipThis work was supported, in whole or in part, by the National Institutes of Health grant CA283524 (to PC) and the UNTHSC Seed Grant to PC and IWP. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
dc.identifier.citationChaudhary, P., Proulx, J., & Park, I. W. (2023). Ubiquitin-protein ligase E3A (UBE3A) mediation of viral infection and human diseases. Virus research, 335, 199191. Advance online publication. https://doi.org/10.1016/j.virusres.2023.199191
dc.identifier.issn1872-7492
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32384
dc.identifier.volume335
dc.publisherElsevier B.V.
dc.relation.urihttps://doi.org/10.1016/j.virusres.2023.199191
dc.rights.holder© 2023 The Authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceVirus Research
dc.subjectE6-AP
dc.subjectHCV
dc.subjectHIV-1
dc.subjectHPV
dc.subjectUBE3A
dc.subjectUbiquitin
dc.subjectUbiquitin Proteasome System (UPS)
dc.titleUbiquitin-protein ligase E3A (UBE3A) mediation of viral infection and human diseases
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dc.type.materialArticle

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