Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study

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dc.creatorRobinson, Michelle D.
dc.creatorMishra, Ina
dc.creatorDeodhar, Sneha
dc.creatorPatel, Vipulkumar
dc.creatorGordon, Katrina V.
dc.creatorVintimilla, Raul
dc.creatorBrown, Kim
dc.creatorJohnson, Leigh A.
dc.creatorO'Bryant, Sid E.
dc.creatorCistola, David P.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid)
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.date.accessioned2022-11-17T21:59:24Z
dc.date.available2022-11-17T21:59:24Z
dc.date.issued2017-12-19
dc.description.abstractBACKGROUND: Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on early detection and intervention in order to preserve pancreatic beta-cells and arterial wall integrity. Yet, the clinical criteria for MetS are insensitive to the early-stage insulin resistance, inflammation, cholesterol and clotting factor abnormalities that characterize the progression toward type 2 diabetes and atherosclerosis. Here we report the discovery and initial characterization of an atypical new biomarker that detects these early conditions with just one measurement. METHODS: Water T2, measured in a few minutes using benchtop nuclear magnetic resonance relaxometry, is exquisitely sensitive to metabolic shifts in the blood proteome. In an observational cross-sectional study of 72 non-diabetic human subjects, the association of plasma and serum water T2 values with over 130 blood biomarkers was analyzed using bivariate, multivariate and logistic regression. RESULTS: Plasma and serum water T2 exhibited strong bivariate correlations with markers of insulin, lipids, inflammation, coagulation and electrolyte balance. After correcting for confounders, low water T2 values were independently and additively associated with fasting hyperinsulinemia, dyslipidemia and subclinical inflammation. Plasma water T2 exhibited 100% sensitivity and 87% specificity for detecting early insulin resistance in normoglycemic subjects, as defined by the McAuley Index. Sixteen normoglycemic subjects with early metabolic abnormalities (22% of the study population) were identified by low water T2 values. Thirteen of the 16 did not meet the harmonized clinical criteria for metabolic syndrome and would have been missed by conventional screening for diabetes risk. Low water T2 values were associated with increases in the mean concentrations of 6 of the 16 most abundant acute phase proteins and lipoproteins in plasma. CONCLUSIONS: Water T2 detects a constellation of early abnormalities associated with metabolic syndrome, providing a global view of an individual's metabolic health. It circumvents the pitfalls associated with fasting glucose and hemoglobin A1c and the limitations of the current clinical criteria for metabolic syndrome. Water T2 shows promise as an early, global and practical screening tool for the identification of individuals at risk for diabetes and atherosclerosis.
dc.description.sponsorshipThis work was supported by institutional start-up funds (to D.P.C.) from the University of North Texas Health Science Center, Fort Worth and the Texas Tech University Health Sciences Center El Paso, as well as a grant from the Garvey Texas Foundation. The Health & Aging Brain Study, which provided some of the subjects and data for this study, is supported by NIA/NIH Grant R01AG039389 (to S.O.) and the UNT Health Science Center. Additional funding was received from the Hogg Foundation, the Institute for Aging and Alzheimer's Disease Research and the Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas.
dc.identifier.citationRobinson, M. D., Mishra, I., Deodhar, S., Patel, V., Gordon, K. V., Vintimilla, R., Brown, K., Johnson, L., O'Bryant, S., & Cistola, D. P. (2017). Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study. Journal of translational medicine, 15(1), 258. https://doi.org/10.1186/s12967-017-1359-5
dc.identifier.issn1479-5876
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31938
dc.identifier.volume15
dc.publisherBioMed Central Ltd.
dc.relation.urihttps://doi.org/10.1186/s12967-017-1359-5
dc.rights.holder© The Author(s) 2017.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of Translational Medicine
dc.subjectatherosclerosis, cardiovascular disease
dc.subjectinflammation
dc.subjectdyslipidemia
dc.subjectmagnetic resonance relaxometry
dc.subjectinsulin resistance
dc.subjectmetabolic syndrome
dc.subjectT2
dc.subjecttransverse relaxation time
dc.subjecttype 2 diabetes mellitus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBiomarkers / blood
dc.subject.meshBlood Proteins / metabolism
dc.subject.meshCluster Analysis
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshMagnetic Resonance Spectroscopy
dc.subject.meshMale
dc.subject.meshMetabolic Syndrome / blood
dc.subject.meshMiddle Aged
dc.subject.meshPrincipal Component Analysis
dc.subject.meshROC Curve
dc.subject.meshSensitivity and Specificity
dc.subject.meshWater / metabolism
dc.subject.meshYoung Adult
dc.titleWater T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study
dc.typeArticle
dc.type.materialtext

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