Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes

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dc.creatorFernández-Gaxiola, Ana Cecilia
dc.creatorValdés-Ramos, Roxana
dc.creatorFulda, Kimberly G.
dc.creatorLópez, Ana Laura Guadarrama
dc.creatorMartínez-Carrillo, Beatriz E.
dc.creatorFranks, Susan F.
dc.creatorFernando, Shane I.
dc.creator.orcid0000-0002-5096-2983 (Fulda, Kimberly G.)
dc.date.accessioned2022-06-30T14:29:33Z
dc.date.available2022-06-30T14:29:33Z
dc.date.issued2017-07-26
dc.description.abstractLiver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker of liver disease. Mexican-American adolescents are disproportionately affected by T2DM, while in Mexico its prevalence is emerging. We assessed liver biomarkers and lipid profiles among Mexican and Mexican-American adolescents 10-14 years old with high/low risk of T2DM through a cross-sectional, descriptive study (Texas n = 144; Mexico n = 149). We included family medical histories, anthropometry, and blood pressure. Obesity was present in one-third of subjects in both sites. ALT (UL) was higher (p < 0.001) in high-risk adolescents (23.5 ± 19.5 versus 17.2 ± 13.4 for males, 19.7 ± 11.6 versus 15.1 ± 5.5 for females), in Toluca and in Texas (26.0 ± 14.7 versus 20.0 ± 13.2 for males, 18.2 ± 13.4 versus 14.6 ± 10.1 for females), as well as GGT (UL) (p < 0.001) (18.7 ± 11.1 versus 12.4 ± 2.3 for males, 13.6 ± 5.8 versus 11.5 ± 3.9 for Mexican females; 21.0 ± 6.8 versus 15.4 ± 5.5 for males, 14.3 ± 5.0 versus 13.8 ± 5.3 for females in Texas). We found no differences by sex or BMI. Total cholesterol and HDL were higher among Mexican-Americans (p < 0.001). In conclusion, multiple risk factors were present in the sample. We found differences by gender and between high and low risk for T2DM adolescents in all liver enzymes in both sites.
dc.description.sponsorshipThis study was funded by the Joint UAEM-UNTHSC Research Grant Program.
dc.identifier.citationFernández-Gaxiola, A. C., Valdés-Ramos, R., Fulda, K. G., López, A., Martínez-Carrillo, B. E., Franks, S. F., & Fernando, S. (2017). Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes. Journal of diabetes research, 2017, 4262536. https://doi.org/10.1155/2017/4262536
dc.identifier.issn2314-6753
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31236
dc.identifier.volume2017
dc.publisherHindawi
dc.relation.urihttps://doi.org/10.1155/2017/4262536
dc.rights.holderCopyright © 2017 Ana Cecilia Fernández-Gaxiola et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of Diabetes Research
dc.subject.meshAdolescent
dc.subject.meshAlanine Transaminase
dc.subject.meshBiomarkers
dc.subject.meshChild
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLipids
dc.subject.meshLiver
dc.subject.meshMale
dc.subject.meshMexican Americans
dc.subject.meshRisk Factors
dc.subject.meshUnited Statest
dc.subject.meshgamma-Glutamyltransferase
dc.titleLiver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes
dc.typeArticle
dc.type.materialtext

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