Depression, inflammation, and memory loss among Mexican Americans: analysis of the HABLE cohort

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dc.creatorJohnson, Leigh A.
dc.creatorEdwards, Melissa
dc.creatorGamboa, Adriana
dc.creatorHall, James R.
dc.creatorRobinson, Michelle
dc.creatorO'Bryant, Sid E.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.date.accessioned2022-07-07T13:54:26Z
dc.date.available2022-07-07T13:54:26Z
dc.date.issued2017-06-20
dc.description.abstractBackground: This study explored the combined impact of depression and inflammation on memory functioning among Mexican-American adults and elders. Methods: Data were analyzed from 381 participants of the Health and Aging Brain study among Latino Elders (HABLE). Fasting serum samples were collected and assayed in duplicate using electrochemiluminesce on the SECTOR Imager 2400A from Meso Scale Discovery. Positive DepE (depression endophenotype) was codified as any score >1 on a five-point scale based on the GDS-30. Inflammation was determined by TNFɑ levels and categorized by tertiles (1st, 2nd, 3rd). WMS-III LMI and LMII as well as CERAD were utilized as measures of memory. ANOVAs examined group differences between positive DepE and inflammation tertiles with neuropsychological scale scores as outcome variables. Logistic regressions were used to examine level of inflammation and DepE positive status on the risk for MCI. Results: Positive DepE as well as higher inflammation were both independently found to be associated with lower memory scores. Among DepE positive, those who were high in inflammation (3rd tertile) were found to perform significantly worse on WMS-III LM I (F = 4.75, p = 0.003), WMS-III LM II (F = 8.18, p < 0.001), and CERAD List Learning (F = 17.37, p < 0.001) when compared to those low on inflammation (1st tertile). The combination of DepE positive and highest tertile of inflammation was associated with increased risk for MCI diagnosis (OR = 6.06; 95% CI = 3.9-11.2, p < 0.001). Conclusion: Presence of elevated inflammation and positive DepE scores increased risk for worse memory among Mexican-American older adults. Additionally, the combination of DepE and high inflammation was associated with increased risk for MCI diagnosis. This work suggests that depression and inflammation are independently associated with worse memory among Mexican-American adults and elders; however, the combination of both increases risk for poorer memory beyond either alone.
dc.description.sponsorshipResearch reported in this publication was supported by the National Institutes of Health under Award Number R01AG039389. This research was also funded with grant from Alzheimer's Association AARG-16-442652, The Pfeiffer foundation, and the National Academy of Neuropsychology.
dc.identifier.citationJohnson, L. A., Edwards, M., Gamboa, A., Hall, J., Robinson, M., & O'Bryant, S. E. (2017). Depression, inflammation, and memory loss among Mexican Americans: analysis of the HABLE cohort. International psychogeriatrics, 29(10), 1693-1699. https://doi.org/10.1017/S1041610217001016
dc.identifier.issn1741-203X
dc.identifier.issue10
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31532
dc.identifier.volume29
dc.publisherCambridge University Press
dc.relation.urihttps://doi.org/10.1017/S1041610217001016
dc.rights.holderCopyright © International Psychogeriatric Association 2017
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Psychogeriatrics
dc.subjectMexican-Americans
dc.subjectdepression endophenotype
dc.subjectDepE
dc.subjectmild cognitive impairment
dc.subject.meshAged
dc.subject.meshCognitive Dysfunction
dc.subject.meshCohort Studies
dc.subject.meshDepression
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMemory Disorders
dc.subject.meshMexican Americans
dc.subject.meshMiddle Aged
dc.subject.meshNeuropsychological Tests
dc.subject.meshRisk Factors
dc.subject.meshUnited States
dc.titleDepression, inflammation, and memory loss among Mexican Americans: analysis of the HABLE cohort
dc.typeArticle
dc.type.materialtext

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