The Role of the IL-23/IL-17 axis and neutrophils during infection with Listeria monocytogenes
| dc.contributor.advisor | Rance Berg, Ph.D | |
| dc.creator | Meeks, Karen D. | |
| dc.date.accessioned | 2019-08-22T21:22:04Z | |
| dc.date.available | 2019-08-22T21:22:04Z | |
| dc.date.issued | 2010-05-01 | |
| dc.date.submitted | 2011-07-11T09:41:33-07:00 | |
| dc.description.abstract | Infection with the gram-positive, intracellular bacteria, Listeria monocytogenes (LM) induces a pro-inflammatory cytokine environment and inflammatory cell influx to sites of infection. The cytokine IL-23 is involved in the maintenance of IL-17A and IL-17F secreting cells which are indirectly required for the recruitment of neutrophils during infection. Neutrophils are thought to be essential for resistance against LM infection; however, their specific role during LM Infection has yet to be defined. By using knockout mice that are deficient in IL-23 or the IL-17 receptor-A, thus devoid of IL-17A and IL-17F signaling, we demonstrate a protective role for the IL-23/IL-17 axis during infection with LM. Our data suggest that the IL-23/IL-17 axis can regulate the continual recruitment of neutrophils into the liver. Furthermore, we demonstrate a protective role for neutrophils. Neutrophils can produce TNF-α, but not IFN-γ during LM infection. Collectively, these data indicate that the IL-23/IL-17 axis and neutrophils are required for resistance against LM infection | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12503/29278 | |
| dc.language.iso | en | |
| dc.provenance.legacyDownloads | 9 | |
| dc.subject | Interleukin-23 | |
| dc.subject | Interleukin-17 | |
| dc.subject | neutrophilis | |
| dc.subject | Listeria monocytogenes | |
| dc.title | The Role of the IL-23/IL-17 axis and neutrophils during infection with Listeria monocytogenes | |
| dc.type | Dissertation | |
| dc.type.material | text | |
| thesis.degree.department | Graduate School of Biomedical Sciences | |
| thesis.degree.grantor | University of North Texas Health Science Center at Fort Worth | |
| thesis.degree.name | Doctor of Philosophy |