The Functional Role of Human 2B4 (CD244) Isoforms in Natural Killer Cells

Simple item page
dc.contributor.advisorPorunelloor Mathew
dc.contributor.committeeMemberRance Berg
dc.contributor.committeeMemberHarlan Jones
dc.creatorRao, Krithi K.
dc.date.accessioned2019-08-22T21:20:59Z
dc.date.available2019-08-22T21:20:59Z
dc.date.issued2007-05-01
dc.date.submitted2014-03-19T06:24:05-07:00
dc.description.abstractRao, Krithi K., Functional role of human 2B4 (CD244) isoforms in natural killer cells. Master of Science (Immunology), July, 2007, 66 pp., 15 illustrations, bibliography. Natural killer (NK) cells are a subpopulation of lymphoctyes that play an important role against tumor metastasis and various viral and bacterial infections. NK cell functions are controlled by a balance between positive and negative signals through various receptors. We have identified, cloned, and characterized the 2B4 (CD244) receptor in mice and human. 2B4 is involved in killing cancer cells and virus-infected cells by NK cells. 2B4 is involved in killing cancer cells and virus-infected cells by NK cells. 2B4 is a counter-receptor for CD48 and recent findings show that 2B4-CD48 interactions plan an important role in NK, T and B cell functions. In humans, two isoforms of 2B4, h2B4-A and h2B4-B, are expressed that differ in the extracellular domain. In the present investigation, we have studied the functions of h2B4-A and h2B4-B. Our data demonstrate that these two isoforms differ in their binding affinity for CD48, resulting in differential cytolytic function as well as cytokine production by NK cells. Thus, differential expression of 2B4 isoforms by NK cells may regulate immune responses mediated through 2B4-CD48 interactions.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29264
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCancer Biology
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectImmunity
dc.subjectImmunology and Infectious Disease
dc.subjectImmunopathology
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedical Immunology
dc.subjectMedicine and Health Sciences
dc.subjectOther Cell and Developmental Biology
dc.subjectOther Immunology and Infectious Disease
dc.subjectFunctional role
dc.subjecthuman
dc.subject2B4
dc.subjectCD244
dc.subjectisoforms
dc.subjectnatural killer cells
dc.subjectlymphocytes
dc.subjectmice
dc.subjectcancer cells
dc.subjectvirus-infected cells
dc.subjectimmune responses Cd48
dc.titleThe Functional Role of Human 2B4 (CD244) Isoforms in Natural Killer Cells
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineMicrobiology and Immunology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rao_TheFunctionalRoleOf.pdf
Size:
14.83 MB
Format:
Adobe Portable Document Format
Download

Collections

School of Biomedical Sciences
Theses and Dissertations