Validation of the Laboratory Information Systems Applications (LISA): Kinship Analysis Module

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dc.creatorEscobedo, Israel
dc.date.accessioned2019-08-22T20:09:45Z
dc.date.available2019-08-22T20:09:45Z
dc.date.issued2008-11-01
dc.date.submitted2014-05-05T12:18:05-07:00
dc.description.abstractEscobedo, Israel, Validation of the Laboratory Information Systems Applications (LISA): Kinship Analysis Module. Master of Science (Biomedical Sciences), December 2008, 155 pp., 10 tables, 21 figures, references, 34 titles. The Laboratory Information Systems Applications (LISA) is a LIMS system designed for the management and analysis of genetic data from large scale investigations of human identification. The validation study evaluated the pedigree construction and analytical tools of the Kinship Analysis module. The genetic data from old paternity cases was used to construct pedigrees under several scenarios that stimulate situations involving a missing child/parent. Each pedigree was analyzed to obtain a KI that measures the strength of the observed genetic evidence for an association made between a missing/deceased individual and a family reference pedigree to make identification. A common distribution of the number of observations per range of the 1n KI was observed in all scenarios. A concordance and reproducibility study was conducted for eight families using a validated kinship analytical program. LISA has the potential of becoming an efficient tool for human identification despite the limitations of the software.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/27946
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCell and Developmental Biology
dc.subjectComputational Biology
dc.subjectEquipment and Supplies
dc.subjectForensic Science and Technology
dc.subjectGenetics
dc.subjectGenetics and Genomics
dc.subjectGenetic Structures
dc.subjectHealth Information Technology
dc.subjectInvestigative Techniques
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectOther Genetics and Genomics
dc.subjectValidation
dc.subjectlaboratory information systems application
dc.subjectkinship analysis module
dc.subjectgenetic data
dc.subjectpaternity cases
dc.subjectgenetic evidence
dc.subjectidentification
dc.subjectsoftware
dc.subjectDNA
dc.titleValidation of the Laboratory Information Systems Applications (LISA): Kinship Analysis Module
dc.typeProfessional Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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