Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing

Date

2023-06-10

Authors

Estrada-Sanchez, Ana M.
Rangel-Barajas, Claudia
Howe, Andrew G.
Barton, Scott J.
Mach, Robert H.
Luedtke, Robert R.
Rebec, George V.

ORCID

0000-0001-8469-2371 (Luedtke, Robert R.)

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

D3 receptors, a key component of the dopamine system, have emerged as a potential target of therapies to improve motor symptoms across neurodegenerative and neuropsychiatric conditions. In the present work, we evaluated the effect of D3 receptor activation on the involuntary head twitches induced by 2,5-dimethoxy-4-iodoamphetamine (DOI) at behavioral and electrophysiological levels. Mice received an intraperitoneal injection of either a full D3 agonist, WC 44 [4-(2-fluoroethyl)-N-[4-[4-(2-methoxyphenyl)piperazin 1-yl]butyl]benzamide] or a partial D3 agonist, WW-III-55 [N-(4-(4-(4-methoxyphenyl)piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamide] five minutes before the intraperitoneal administration of DOI. Compared to the control group, both D3 agonists delayed the onset of the DOI-induced head-twitch response and reduced the total number and frequency of the head twitches. Moreover, the simultaneous recording of neuronal activity in the motor cortex (M1) and dorsal striatum (DS) indicated that D3 activation led to slight changes in a single unit activity, mainly in DS, and increased its correlated firing in DS or between presumed cortical pyramidal neurons (CPNs) and striatal medium spiny neurons (MSNs). Our results confirm the role of D3 receptor activation in controlling DOI-induced involuntary movements and suggest that this effect involves, at least in part, an increase in correlated corticostriatal activity. A further understanding of the underlying mechanisms may provide a suitable target for treating neuropathologies in which involuntary movements occur.

Description

Citation

Estrada-Sánchez, A. M., Rangel-Barajas, C., Howe, A. G., Barton, S. J., Mach, R. H., Luedtke, R. R., & Rebec, G. V. (2023). Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing. International journal of molecular sciences, 24(11), 9300. https://doi.org/10.3390/ijms24119300

Rights

© 2023 by the authors.

License

Attribution 4.0 International (CC BY 4.0)