Effects of Exercise Training on the Autophagy-Related Muscular Proteins Expression in Ovariectomized Rats

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dc.creatorZhong, Weiquan
dc.creatorShi, Xiangrong
dc.creatorYuan, Honghua
dc.creatorBu, Huimin
dc.creatorWu, Lianlian
dc.creatorWang, Renwei
dc.date.accessioned2022-11-28T20:48:00Z
dc.date.available2022-11-28T20:48:00Z
dc.date.issued2019-06-13
dc.description.abstractOvariectomy disrupts estrogen production and homeostasis. However, whether exercise training (ET) could counteract the ovariectomy-induced effect on muscular autophagy has remained elusive. This study examined muscular autophagy in ovariectomized (OVX) rats following 8 weeks of swimming ET. Here, 40 6-month-old female Sprague-Dawley rats were randomly divided into five groups: sham-operated control (Sham), OVX control (OVX), OVX with 60-min ET (OVX-60ET), 90-min ET (OVX-90ET), and 120-min ET (OVX-120ET) for 6 days/week. According to the results of Western blotting, the expression levels of autophagy-related proteins in the OVX gastrocnemius muscle, including mammalian target of rapamycin, uncoordinated 51-like kinase 1, Beclin-1, autophagy-related gene (Atg-7), and microtubule-associated protein light chains 3 were significantly decreased (all P < 0.05), while there was an elevation on the p62 level. ET appreciably mitigated the OVX-induced negative effects on muscle quality and the autophagy pathway, which seemed to be dependent on ET volume. The most optimal outcomes were observed in the OVX-90ET group. The OVX-120 group had an adversely augmented catabolic process associated with gastrocnemius muscle atrophy. In conclusion, the expression levels of autophagy proteins are decreased in OVX rats, which can be appreciably mitigated following 8 weeks of swimming ET.
dc.description.sponsorshipThis study was supported by Shanghai Key Lab of Human Performance (Shanghai University of Sport) (No. 11DZ2261100) and Rehabilitation Medicine Brand Profession, Xuzhou Medical University
dc.identifier.citationZhong, W., Shi, X., Yuan, H., Bu, H., Wu, L., & Wang, R. (2019). Effects of Exercise Training on the Autophagy-Related Muscular Proteins Expression in Ovariectomized Rats. Frontiers in physiology, 10, 735. https://doi.org/10.3389/fphys.2019.00735
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31977
dc.identifier.volume10
dc.publisherFrontiers Media S.A.
dc.relation.urihttps://doi.org/10.3389/fphys.2019.00735
dc.rights.holder© 2019 Zhong, Shi, Yuan, Bu, Wu and Wang.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Physiology
dc.subjectautophagy
dc.subjectbody weight
dc.subjectovariectomy
dc.subjectskeletal muscle
dc.subjectswimming exercise
dc.titleEffects of Exercise Training on the Autophagy-Related Muscular Proteins Expression in Ovariectomized Rats
dc.typeArticle
dc.type.materialtext

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