Pharmacological Evaluation of the D2 and D3 Dopamine Receptor Selective Compounds on L-Dopa Dependent Abnormal Involuntary Movements in Rats

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dc.contributor.advisorRobert Luedtke
dc.contributor.committeeMemberHriday K. Das
dc.contributor.committeeMemberNathalie Sumien
dc.creatorKumar, Rakesh
dc.date.accessioned2019-08-22T19:28:45Z
dc.date.available2019-08-22T19:28:45Z
dc.date.issued2008-05-01
dc.date.submitted2014-02-24T07:00:05-08:00
dc.description.abstractKumar Rakesh, Pharmacological Evaluation of the D2 and D3 Dopamine Receptor Selective Compounds on L-dopa Dependent Abnormal Involuntary Movements in Rats. Master of Science (Pharmacology & Neuroscience), May 2008, 106 pp, 21 illustrations, references, 31 titles. Parkinson’s Disease (PD) is a progressive, neurodegenerative disease of the dopamine neurons that innervate the striatum and is characterized by resting tremor, rigidity, bardykinesia and postural instability. L-dopa treatment is the most common and effective therapy for PD. However, both motor (wear-off phenomena, rigidity and dyskinesia) and non-motor (sweating, tachycardia, restless leg syndrome, anxiety, depression, confusion, reduced alertness, psychosis and/or dementia) side effects are associated with long term L-dopa therapy. Motor complications depend on the duration of L-dopa treatment and the abnormal involuntary movements are known as L-dopa-induced dyskinesia (LID). Several studies have suggested a possible role of the dopamine D3 receptor subtype in LID. Here I evaluated the effects of various D2 and D3 dopamine receptor selective compounds on LID in 6-hydroxydopamine-induced complete lesioned hemi-parkinsonian model of rat. D3 dopamine receptor selective compounds (agonists, partial agonists or antagonists) have antidyskinetic effects on LID. Co-administration of D3 dopamine receptor agonist and D3 dopamine receptor antagonist has additive effects in attenuating the LID instead of antagonizing the effects of each other in vivo. D3 dopamine receptor selective compounds attenuated apomorphine-induced dyskinesia.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/25770
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCell and Developmental Biology
dc.subjectChemicals and Drugs
dc.subjectDiseases
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectNervous System Diseases
dc.subjectOther Cell and Developmental Biology
dc.subjectOther Pharmacy and Pharmaceutical Sciences
dc.subjectPharmaceutics and Drug Design
dc.subjectPharmacology
dc.subjectPharmacy and Pharmaceutical Sciences
dc.subjectPharmacological evaluation
dc.subjectD2
dc.subjectD3
dc.subjectdopamine receptor selective compounds
dc.subjectL-dopa dependent abnormal involuntary movements
dc.subjectrats
dc.subjectParkinson’s Disease
dc.subjecttreatment
dc.subjectmotor complications
dc.subjectLID
dc.subjectL-dopa-induced dyskinesia
dc.subject6-hydroxydopamine-induced complete lesioned hemi-parkinsonian model
dc.subjectapomorphine-induced
dc.titlePharmacological Evaluation of the D2 and D3 Dopamine Receptor Selective Compounds on L-Dopa Dependent Abnormal Involuntary Movements in Rats
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplinePharmacology and Neuroscience
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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