Factors associated with HPV vaccination intention among U.S. 27-45-year-olds

Introduction: HPV vaccination recommendations now include shared clinical decision-making for adults aged 27-45 years. We investigated how knowledge, attitudes, and beliefs were associated with likelihood of asking a healthcare provider about the HPV vaccine and the likelihood of getting the HPV vaccine among adults ages 27-45 years old. Methods: A cross-sectional survey was distributed to U.S. adults between 27-45 years old between April-May 2020 (n=691). Outcomes of interest included likelihood of asking their provider about the HPV vaccine and likelihood of getting the HPV vaccine. Covariates included demographic factors, knowledge, attitudes, and beliefs. Adjusted models were estimated for each outcome variable using a log function and Poisson distribution. Results: Likelihood of asking their provider about the HPV vaccine was significantly associated with perceived likelihood of benefitting from the vaccine (aOR=2.45, 95% CI: 1.69-3.57). Likelihood of receiving the vaccine was associated with HPV vaccine attitudes (aOR=1.04, 95% CI:1.01-1.07), perceived effectiveness against HPV infection (aOR=4.03, 95% CI=1.20-13.53), and perceived likelihood of benefitting from the vaccine (aOR=4.31, 95% CI=2.64-7.03). Conclusions: These findings suggest increasing positive vaccine attitudes, perceived effectiveness, and perceived likelihood of benefitting from the vaccination are important factors in facilitating a shared clinical decision for HPV vaccination. Understanding factors associated with likelihood of discussing and receiving the HPV vaccine among 27-45-year-olds is important to implement guidelines for shared clinical decision-making.