Hyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation

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dc.creatorLi, Wenjun
dc.creatorRoy Choudhury, Gourav
dc.creatorWinters, Ali
dc.creatorPrah, Jude
dc.creatorLin, Wenping
dc.creatorLiu, Ran
dc.creatorYang, Shaohua
dc.creator.orcid0000-0002-3882-0616 (Liu, Ran)
dc.creator.orcid0000-0002-0405-0887 (Yang, Shaohua)
dc.date.accessioned2022-11-28T20:48:02Z
dc.date.available2022-11-28T20:48:02Z
dc.date.issued2018-08-01
dc.description.abstractDiabetes milieu is a complex metabolic disease that has been known to associate with high risk of various neurological disorders. Hyperglycemia in diabetes could dramatically increase neuronal glucose levels which leads to neuronal damage, a phenomenon referred to as glucose neurotoxicity. On the other hand, the impact of hyperglycemia on astrocytes has been less explored. Astrocytes play important roles in brain energy metabolism through neuron-astrocyte coupling. As the component of blood brain barrier, glucose might be primarily transported into astrocytes, hence, impose direct impact on astrocyte metabolism and function. In the present study, we determined the effect of high glucose on the energy metabolism and function of primary astrocytes. Hyperglycemia level glucose (25 mM) induced cell cycle arrest and inhibited proliferation and migration of primary astrocytes. Consistently, high glucose decreased cyclin D1 and D3 expression. High glucose enhanced glycolytic metabolism, increased ATP and glycogen content in primary astrocytes. In addition, high glucose activated AMP-activated protein kinase (AMPK) signaling pathway in astrocytes. In summary, our in vitro study indicated that hyperglycemia might impact astrocyte energy metabolism and function phenotype. Our study provides a potential mechanism which may underlie the diabetic cerebral neuropathy and warrant further in vivo study to determine the effect of hyperglycemia on astrocyte metabolism and function.
dc.description.sponsorshipThis work was partly supported by National Institutes of Health grants 1R21NS087209-01A1 (SY) and R01NS088596 (SY).
dc.identifier.citationLi, W., Roy Choudhury, G., Winters, A., Prah, J., Lin, W., Liu, R., & Yang, S. H. (2018). Hyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation. Aging and disease, 9(4), 674-684. https://doi.org/10.14336/AD.2017.1208
dc.identifier.issn2152-5250
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31982
dc.identifier.volume9
dc.publisherJKL International
dc.relation.urihttps://doi.org/10.14336/AD.2017.1208
dc.rights.holder© 2017 Li W et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectAMP-activated protein kinase
dc.subjectastrocyte
dc.subjectdiabetes
dc.subjectmetabolism
dc.titleHyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation
dc.typeArticle
dc.type.materialtext

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