Enhancing the Solubility of Valrubicin via Albumin and TPGS Formulations

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dc.contributor.advisorLacko, Andras G.
dc.contributor.committeeMemberBasu, Alakananda
dc.contributor.committeeMemberJones, Harlan P.
dc.contributor.committeeMemberRanjan, Amalendu
dc.creatorDossou, Akpedje
dc.creator.orcid0000-0002-9844-8860 (Dossou, Akpedje)
dc.date.accessioned2019-09-26T19:52:25Z
dc.date.available2019-09-26T19:52:25Z
dc.date.issued2018-08
dc.description.abstractHuman serum albumin (HSA) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) are versatile biocompatible materials used in drug formulation. Due to its lipophilicity, the anticancer drug valrubicin (VALSTAR) has been solubilized with Cremophor EL, a solvent known for its systemic toxicity. While valrubicin is less toxic than its widely used hydrophilic anthracycline analogues, its clinical use is currently restricted to intravesical route for bladder cancer treatment. Because preliminary studies have shown a strong affinity of valrubicin for HSA and TPGS micelles, this study was aimed to explore the potential of reduced HSA (rHSA) or TPGS as excipients for valrubicin. In an aqueous environment, valrubicin solubility was enhanced from 0.1 to 85.4% using rHSA while it was dependent upon TPGS concentration. With appropriate formulation approaches, rHSA or TPGS could serve as valrubicin transporters and could thus, enable its systemic administration and extended use beyond bladder cancer to other cancer types.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29677
dc.language.isoen
dc.subjectValrubicin
dc.subjectalbumin
dc.subjectTPGS
dc.subjectreduced human serum albumin
dc.subjectformulation
dc.subjectmicelles
dc.subjectself-assembly
dc.subject.meshNeoplasms, drug therapy
dc.subject.meshSerum Albumin, Human
dc.subject.meshExcipients
dc.subject.meshDrug Carriers
dc.subject.meshVitamin E
dc.titleEnhancing the Solubility of Valrubicin via Albumin and TPGS Formulations
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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