Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

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dc.creatorLeng, Zikuan
dc.creatorZhu, Rongjia
dc.creatorHou, Wei
dc.creatorFeng, Yingmei
dc.creatorYang, Yanlei
dc.creatorHan, Qin
dc.creatorShan, Guangliang
dc.creatorMeng, Fanyan
dc.creatorDu, Dongshu
dc.creatorWang, Shihua
dc.creatorFan, Junfen
dc.creatorWang, Wenjing
dc.creatorDeng, Luchan
dc.creatorShi, Hongbo
dc.creatorLi, Hongjun
dc.creatorHu, Zhongjie
dc.creatorZhang, Fengchun
dc.creatorGao, Jinming
dc.creatorLiu, Hongjian
dc.creatorLi, Xiaoxia
dc.creatorZhao, Yangyang
dc.creatorYin, Kan
dc.creatorHe, Xijing
dc.creatorGao, Zhengchao
dc.creatorWang, Yibin
dc.creatorYang, Bo
dc.creatorJin, Ronghua
dc.creatorStambler, Ilia
dc.creatorLim, Lee Wei
dc.creatorSu, Huanxing
dc.creatorMoskalev, Alexey
dc.creatorCano, Antonio
dc.creatorChakrabarti, Sasanka
dc.creatorMin, Kyung-Jin
dc.creatorEllison-Hughes, Georgina
dc.creatorCaruso, Calogero
dc.creatorJin, Kunlin
dc.creatorZhao, Robert Chunhua
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.date.accessioned2022-09-09T14:08:44Z
dc.date.available2022-09-09T14:08:44Z
dc.date.issued2020-03-09
dc.description.abstractA coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. This study aims to investigate whether MSC transplantation improves the outcome of 7 enrolled patients with COVID-19 pneumonia in Beijing YouAn Hospital, China, from Jan 23, 2020 to Feb 16, 2020. The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. MSCs could cure or significantly improve the functional outcomes of seven patients without observed adverse effects. The pulmonary function and symptoms of these seven patients were significantly improved in 2 days after MSC transplantation. Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. In addition, a group of CD14+CD11c+CD11b(mid) regulatory DC cell population dramatically increased. Meanwhile, the level of TNF-alpha was significantly decreased, while IL-10 increased in MSC treatment group compared to the placebo control group. Furthermore, the gene expression profile showed MSCs were ACE2(-) and TMPRSS2(-) which indicated MSCs are free from COVID-19 infection. Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.
dc.description.sponsorshipThis work was supported by the National Key Research and Development Program of China (2016YFA0101000, 2018YFE0114200), CAMS Innovation Fund for Medical Sciences (2017-I2M-3-007) and the 111 Project (B18007), National Natural Science Foundation of China (81971324, 81672313, 81700782, 81972523, 81771349).
dc.identifier.citationLeng, Z., Zhu, R., Hou, W., Feng, Y., Yang, Y., Han, Q., Shan, G., Meng, F., Du, D., Wang, S., Fan, J., Wang, W., Deng, L., Shi, H., Li, H., Hu, Z., Zhang, F., Gao, J., Liu, H., Li, X., ... Zhao, R. C. (2020). Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Aging and disease, 11(2), 216-228. https://doi.org/10.14336/AD.2020.0228
dc.identifier.issn2152-5250
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31714
dc.identifier.volume11
dc.publisherJKL International
dc.relation.urihttps://doi.org/10.14336/AD.2020.0228
dc.rights.holder© 2020 Leng Z et al,
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectACE2 negative
dc.subjectCovid-19
dc.subjectcell transplantation
dc.subjectfunction recovery
dc.subjectimmunomodulation
dc.subjectmesenchymal stem cells
dc.titleTransplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia
dc.typeArticle
dc.type.materialtext

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