Higher Expression of Annexin A2 in Metastatic Bladder Urothelial Carcinoma Promotes Migration and Invasion

Simple item page
dc.creatorGuo, Christina
dc.creatorTrivedi, Rucha
dc.creatorTripathi, Amit K.
dc.creatorNandy, Rajesh
dc.creatorWagner, Diana C.
dc.creatorNarra, Kalyani
dc.creatorChaudhary, Pankaj
dc.creator.orcid0000-0003-0518-4120 (Chaudhary, Pankaj)
dc.creator.orcid0000-0002-5164-2367 (Trivedi, Rucha)
dc.date.accessioned2023-01-31T21:40:16Z
dc.date.available2023-01-31T21:40:16Z
dc.date.issued2022-11-27
dc.description.abstractIn this study, we aim to evaluate the significance of AnxA2 in BLCA and establish its metastatic role in bladder cancer cells. Analysis of TCGA data showed that AnxA2 mRNA expression was significantly higher in BLCA tumors than in normal bladder tissues. High mRNA expression of AnxA2 in BLCA was significantly associated with high pathological grades and stages, non-papillary tumor histology, and poor overall survival (OS), progression-free survival (PFS), and diseases specific survival (DSS). Similarly, we found that AnxA2 expression was higher in bladder cancer cells derived from high-grade metastatic carcinoma than in cells derived from low-grade urothelial carcinoma. AnxA2 expression significantly mobilized to the surface of highly metastatic bladder cancer cells compared to cells derived from low-grade tumors and associated with high plasmin generation and AnxA2 secretion. In addition, the downregulation of AnxA2 cells significantly inhibited the proliferation, migration, and invasion in bladder cancer along with the reduction in proangiogenic factors and cytokines such as PDGF-BB, ANGPT1, ANGPT2, Tie-2, bFGF, GRO, IL-6, IL-8, and MMP-9. These findings suggest that AnxA2 could be a promising biomarker and therapeutic target for high-grade BLCA.
dc.description.sponsorshipThis research was partly supported by the National Institutes of Health grants CA233355 and HL125447. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
dc.identifier.citationGuo, C., Trivedi, R., Tripathi, A. K., Nandy, R. R., Wagner, D. C., Narra, K., & Chaudhary, P. (2022). Higher Expression of Annexin A2 in Metastatic Bladder Urothelial Carcinoma Promotes Migration and Invasion. Cancers, 14(22), 5664. https://doi.org/10.3390/cancers14225664
dc.identifier.issn2072-6694
dc.identifier.issue22
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32000
dc.identifier.volume14
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/cancers14225664
dc.rights.holder© 2022 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceCancers (Basel)
dc.subjectAnnexin A2
dc.subjectbladder urothelial carcinoma
dc.subjectinvasion
dc.subjectmigration
dc.subjectplasmin
dc.titleHigher Expression of Annexin A2 in Metastatic Bladder Urothelial Carcinoma Promotes Migration and Invasion
dc.typeArticle
dc.type.materialtext

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
full text article
Size:
3.2 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Publications -- Pankaj Chaudhary
Publications -- Rajesh Nandy