Association of Specificity Proteins and Survivin in Colon Adenocarcinoma with an Emphasis on Race/Ethnicity




Basha, Riyaz
Mahajan, Anisha
Kurri, Ananya


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Purpose: Colorectal cancers are the third most common group of cancers worldwide in incidence and mortality, with the most prevalent of those being colon adenocarcinoma (COAD). Mutations in Specificity protein 1 (Sp1) and survivin (baculoviral inhibitor of apoptosis repeat-containing 5) have been well associated with tumorigenesis, however their impact on COAD prognosis remains unclear. The purpose of this study was to evaluate the expression levels of Sp1 and survivin in COAD clinical specimens, their impact on patient survival rates, and association with racial/ethnic disparities. Methods: Data was analyzed using two online databases: 'R2 genomics visualization platform' and 'University of Alabama Cancer Database (UALCAN)'. R2 was used to generate Kaplan-Meier curves for COAD patients with tumors expressing Sp1 and survivin (n=155 patients). UALCAN was used to generate COAD patient survival probabilities in association with race/ethnicity (n=256 patients) of African American (AA), Asian, and Caucasian descent. Results: Sp1 and survivin are overexpressed in COAD tumors and the survival curves demonstrated a link between high levels of Sp1 and survivin expression in COAD patients with a significantly poorer prognosis compared to patients with low levels of expression (Sp1, p=0.0047; survivin, p=0.041). Additionally, the survival curves revealed racial/ethnic disparities. The overexpression of Sp1 and survivin is prevalent among African American patients, correlating with poorer outcomes. Conclusion: The overexpression of Sp1 and survivin is significantly associated with poor prognosis in COAD patients, especially in African Americans. Targeting these markers can improve survival outcomes in COAD patients and address cancer health disparities.