Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos

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dc.creatorDoum, Dyna
dc.creatorOvergaard, Hans J.
dc.creatorMayxay, Mayfong
dc.creatorSuttiprapa, Sutas
dc.creatorSaichua, Prasert
dc.creatorEkalaksananan, Tipaya
dc.creatorTongchai, Panwad
dc.creatorRahman, Md. Siddikur
dc.creatorHaque, Ubydul
dc.creatorPhommachanh, Sysavanh
dc.creatorPongvongsa, Tiengkham
dc.creatorRocklov, Joacim
dc.creatorPaul, Richard
dc.creatorPientong, Chamsai
dc.creator.orcid0000-0002-7413-1017 (Haque, Ubydul)
dc.date.accessioned2022-09-06T20:07:19Z
dc.date.available2022-09-06T20:07:19Z
dc.date.issued2020-12-07
dc.description.abstractDengue is the most rapidly spreading mosquito-borne viral disease in the world. The detection of clinical cases enables us to measure the incidence of dengue infection, whereas serological surveys give insights into the prevalence of infection. This study aimed to determine dengue seroprevalence and seroconversion rates in northeastern Thailand and southern Laos and to assess any association of mosquito control methods and socioeconomic factors with dengue virus (DENV) infection. Cross-sectional seroprevalence surveys were performed in May and November 2019 on the same individuals. Blood samples were collected from one adult and one child, when possible, in each of 720 randomly selected households from two urban and two rural sites in both northeastern Thailand and southern Laos. IgG antibodies against DENV were detected in serum using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Overall, 1071 individuals participated in the study. The seroprevalence rate was high (91.5%) across all 8 study sites. Only age and province were associated with seroprevalence rates. There were 33 seroconversions during the period from May to November, of which seven reported fever. More than half of the seroconversions occurred in the rural areas and in Laos. Dengue seroconversion was significantly associated with young age (<15 years old), female gender, province, and duration of living in the current residence. No socioeconomic factors or mosquito control methods were found to be associated with seroprevalence or seroconversion. Notably, however, the province with most seroconversions had lower diurnal temperature ranges than elsewhere. In conclusion, our study has highlighted the homogeneity of dengue exposure across a wide range of settings and most notably those from rural and urban areas. Dengue can no longer be considered to be solely an urban disease nor necessarily one linked to poverty.
dc.description.sponsorshipThe project was funded by the Research Council of Norway (project no. 281077) and Khon Kaen University Faculty of Medicine Research Grant (no. IN63223).
dc.identifier.citationDoum, D., Overgaard, H. J., Mayxay, M., Suttiprapa, S., Saichua, P., Ekalaksananan, T., Tongchai, P., Rahman, M. S., Haque, U., Phommachanh, S., Pongvongsa, T., Rocklöv, J., Paul, R., & Pientong, C. (2020). Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos. International journal of environmental research and public health, 17(23), 9134. https://doi.org/10.3390/ijerph17239134
dc.identifier.issn1660-4601
dc.identifier.issue23
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31674
dc.identifier.volume17
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/ijerph17239134
dc.rights.holder© 2020 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Environmental Research and Public Health
dc.subjectdenv
dc.subjectdengue
dc.subjectseroconversion
dc.subjectseroprevalence
dc.subjectsocioeconomic factors
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnimals
dc.subject.meshAntibodies, Viral
dc.subject.meshChild
dc.subject.meshCross-Sectional Studies
dc.subject.meshDengue Virus / immunology
dc.subject.meshDengue / epidemiology
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLaos / epidemiology
dc.subject.meshMale
dc.subject.meshRural Population
dc.subject.meshSeroconversion
dc.subject.meshSeroepidemiologic Studies
dc.subject.meshThailand / epidemiology
dc.titleDengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos
dc.typeArticle
dc.type.materialtext

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