Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation

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dc.creatorLin, Shao-Peng
dc.creatorLi, Wenjun
dc.creatorWinters, Ali
dc.creatorLiu, Ran
dc.creatorYang, Shaohua
dc.creator.orcid0000-0002-3882-0616 (Liu, Ran)
dc.creator.orcid0000-0002-0405-0887 (Yang, Shaohua)
dc.date.accessioned2022-11-28T20:48:03Z
dc.date.available2022-11-28T20:48:03Z
dc.date.issued2018-04-20
dc.description.abstractArtemisinin is an anti-malarial drug that has been in use for almost half century. Recently, novel biological effects of artemisinin on cancer, inflammation-related disorders and cardiovascular disease were reported. However, neuroprotective actions of artemisinin against glutamate-induced oxidative stress have not been investigated. In the current study, we determined the effect of artemisinin against oxidative insult in HT-22 mouse hippocampal cell line. We found that pretreatment of artemisinin declined reactive oxygen species (ROS) production, attenuated the collapse of mitochondrial membrane potential induced by glutamate and rescued HT-22 cells from glutamate-induced cell death. Furthermore, our study demonstrated that artemisinin activated Akt/Bcl-2 signaling and that neuroprotective effect of artemisinin was blocked by Akt-specific inhibitor, MK2206. Taken together, our study indicated that artemisinin prevented neuronal HT-22 cell from glutamate-induced oxidative injury by activation of Akt signaling pathway.
dc.description.sponsorshipThis work was partly supported by the National Natural Science Foundation of China (Grant No. 81641088), the Natural Science Foundation of Guangdong Province (Grant No. 2016A030310267), the Science and Technology Planning Project of Guangdong Province (Grant No. 2015A030302091), the Science and Technology Planning Project of Guangzhou (Grant No. 201607010160), the Nature Science Foundation in Guangzhou Medical University (Grant No. 2015C14) and the Key Medical Disciplines and Specialities Program of Guangzhou.
dc.identifier.citationLin, S. P., Li, W., Winters, A., Liu, R., & Yang, S. H. (2018). Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Frontiers in cellular neuroscience, 12, 108. https://doi.org/10.3389/fncel.2018.00108
dc.identifier.issn1662-5102
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31985
dc.identifier.volume12
dc.publisherFrontiers Media S.A.
dc.relation.urihttps://doi.org/10.3389/fncel.2018.00108
dc.rights.holder© 2018 Lin, Li, Winters, Liu and Yang.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Cellular Neuroscience
dc.subjectAkt
dc.subjectapoptosis
dc.subjectartemisinin
dc.subjectneuroprotection
dc.subjectoxidative stress
dc.titleArtemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation
dc.typeArticle
dc.type.materialtext

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