STAT6 and Its Relationship with PSA and Annexin A2 in Human Prostate Cancer

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dc.contributor.advisorSingh, Meharvan
dc.contributor.committeeMemberJones, Harlan P.
dc.contributor.committeeMemberSharma, Rajendra
dc.creatorRoth, Cherice P.
dc.date.accessioned2019-08-22T21:38:21Z
dc.date.available2019-08-22T21:38:21Z
dc.date.issued2008-05-01
dc.date.submitted2014-03-31T08:36:05-07:00
dc.description.abstractRoth, Cherice, STAT6 and its relationship with PSA and Annexin A2 in Human Prostate Cancer. Master of Science (Biochemistry and Molecular Biology), May 2008, 49 pages, 13 illustrations, reference list, 54 titles. The increase of signal transducer and activator of transcription (STAT6) has been correlated with increased prostate tumor size as well as Gleason score. This molecule’s exact role in prostate cancer is still unknown. This research focused on the relationships of STAT6 in prostate specific antigen (PSA) expression as well as its novel interaction with annexin A2. These data show that STAT6 is involved in an alternate PSA expression pathway. It is also concluded that the interaction of STAT6 and annexin A2 increased the activated STAT6 (p-STAT) but not total STAT6. Chromatin immunoprecipitation also confirmed the novel protein-protein interaction between STAT6 and annexin A2 is nuclear.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29478
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectBiochemistry
dc.subjectCancer Biology
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectDiseases
dc.subjectLife Sciences
dc.subjectMale Urogenital Diseases
dc.subjectMedical Cell Biology
dc.subjectMedical Molecular Biology
dc.subjectMedicine and Health Sciences
dc.subjectMicrobiology
dc.subjectMolecular Biology
dc.subjectOncology
dc.subjectOther Cell and Developmental Biology
dc.subjectReproductive and Urinary Physiology
dc.subjectSTAT6
dc.subjectrelationship
dc.subjectPSA
dc.subjectAnnexin A2
dc.subjecthuman prostate cancer
dc.subjectsignal transducer and activator of transcription
dc.subjectprostate tumor size
dc.subjectGleason score
dc.subjectmolecule
dc.subjectrole
dc.subjectexpression pathway
dc.subjectchromatin immunoprecipitation
dc.subjectprotein-protein interaction
dc.titleSTAT6 and Its Relationship with PSA and Annexin A2 in Human Prostate Cancer
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiochemistry and Molecular Biology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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