The Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India

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dc.creatorChakrabarti, Sankha Shubhra
dc.creatorKaur, Upinder
dc.creatorAggarwal, Sushil Kumar
dc.creatorKanakan, Ahalya
dc.creatorSaini, Adesh
dc.creatorAgrawal, Bimal Kumar
dc.creatorJin, Kunlin
dc.creatorChakrabarti, Sasanka
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.date.accessioned2022-09-09T14:08:43Z
dc.date.available2022-09-09T14:08:43Z
dc.date.issued2022-02-01
dc.description.abstractThere has been a surge of mucormycosis cases in India in the wake of the second wave of COVID-19 with more than 40000 cases reported. Mucormycosis in patients of COVID-19 in India is at variance to other countries where Aspergillus, Pneumocystis, and Candida have been reported to be the major secondary fungal pathogens. We discuss the probable causes of the mucormycosis epidemic in India. Whereas dysglycaemia and inappropriate steroid use have been widely suggested as tentative reasons, we explore other biological, iatrogenic, and environmental factors. The likelihood of a two-hit pathogenesis remains strong. We propose that COVID-19 itself provides the predisposition to invasive mucormycosis (first hit), through upregulation of GRP78 and downregulation of spleen tyrosine kinase involved in anti-fungal defense, as also through inhibition of CD8+ T-cell mediated immunity. The other iatrogenic and environmental factors may provide the second hit which may have resulted in the surge.
dc.identifier.citationChakrabarti, S. S., Kaur, U., Aggarwal, S. K., Kanakan, A., Saini, A., Agrawal, B. K., Jin, K., & Chakrabarti, S. (2022). The Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India. Aging and disease, 13(1), 24-28. https://doi.org/10.14336/AD.2021.0811
dc.identifier.issn2152-5250
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31707
dc.identifier.volume13
dc.publisherJKL International
dc.relation.urihttps://doi.org/10.14336/AD.2021.0811
dc.rights.holder© 2021 Chakrabart SS. et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectGrp78
dc.subjectRhizopus
dc.subjectrhino-orbito-cerebral
dc.subjectspleen tyrosine kinase
dc.titleThe Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India
dc.typeArticle
dc.type.materialtext

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