SDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke

Simple item page
dc.creatorZhang, Yu
dc.creatorZhang, Hongxia
dc.creatorLin, Siyang
dc.creatorChen, Xudong
dc.creatorYao, Yu
dc.creatorMao, XiaoOu
dc.creatorShao, Bei
dc.creatorZhuge, Qichuan
dc.creatorJin, Kunlin
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.creator.orcid0000-0003-1594-6707 (Zhang, Hongxia)
dc.date.accessioned2022-09-09T14:08:43Z
dc.date.available2022-09-09T14:08:43Z
dc.date.issued2018-04-01
dc.description.abstractStromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptors CXCR4 and CXCR7 play important roles in brain repair after ischemic stroke, as SDF-1/ CXCR4/CXCR7 chemokine signaling is critical for recruiting stem cells to sites of ischemic injury. Upregulation of SDF-1/CXCR4/CXCR7 chemokine signaling in the ischemic regions has been well-documented in the animal models of ischemic stroke, but not in human ischemic brain. Here, we found that protein expression of SDF-1 and CXCR7, but not CXCR4, were significantly increased in the cortical peri-infarct regions (penumbra) after ischemic stroke in human, compared with adjacent normal tissues and control subjects. Double-label fluorescence immunohistochemistry shows that SDF-1 and CXCR4 proteins were expressed in neuronal cells and astrocytes in the normal brain tissue and peri-infarct regions. CXCR7 protein was also observed in neuronal cells and astrocytes in the normal cortical regions, but predominantly in astrocytes in the penumbra of ischemic brain. Our data suggest that ischemic stroke in human leads to an increase in the expression of SDF-1 and CXCR7, but not CXCR4, in the peri-infarct cerebral cortex. Our findings suggest that chemokine SFD-1 is expressed not only in animal models of stroke, but also in the human brain after an ischemic injury. In addition, unlike animals, CXCR7 may be the primary receptor of SDF-1 in human stroke brain.
dc.description.sponsorshipThis work was supported by National Institute of Health (NIH) grants R21NS094859 and AG21980 (J.K), National Natural Science Foundation of China (81371396, 81778262; Q. Z.G), and Key research project of Science Technology Department of Zhejiang Province (NO2017C03027; Q.Z.G), and Wenzhou public welfare science and technology project (Y20170089; Y.Z).
dc.identifier.citationZhang, Y., Zhang, H., Lin, S., Chen, X., Yao, Y., Mao, X., Shao, B., Zhuge, Q., & Jin, K. (2018). SDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke. Aging and disease, 9(2), 287-295. https://doi.org/10.14336/AD.2017.1112
dc.identifier.issn2152-5250
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31712
dc.identifier.volume9
dc.publisherJKL International
dc.relation.urihttps://doi.org/10.14336/AD.2017.1112
dc.rights.holder© 2017 Zhang Y et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectCxcl12
dc.subjectCxcr4
dc.subjectCxcr7
dc.subjectSdf-1
dc.subjectchemokine
dc.subjecthuman
dc.subjectischemia
dc.subjectpatient
dc.subjectpenumbra
dc.subjectstroke
dc.titleSDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke
dc.typeArticle
dc.type.materialtext

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.14336_AD.2017.1112.pdf
Size:
764.7 KB
Format:
Adobe Portable Document Format
Description:
full text article
Download

Collections

Publications -- Kunlin Jin