Association of Survivin in Liver Hepatocellular Carcinoma Patient Survival with an Emphasis on Race and Gender
| dc.creator | Tran, Nora | |
| dc.creator | Basha, Riyaz | |
| dc.creator | Ibarra-Aleman, Victoria | |
| dc.creator | Spore, Paul | |
| dc.creator.orcid | 0000-0003-2086-5530 (Tran, Nora) | |
| dc.date.accessioned | 2021-04-30T14:26:06Z | |
| dc.date.available | 2021-04-30T14:26:06Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Purpose: Liver hepatocellular carcinoma (LIHC) represents the most common type of primary liver cancer in many parts of the world. In LIHC, Survivin is associated with increased tumor aggression and a poorer prognosis. Survivin is a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and thus plays a role in several molecular processes, including apoptosis. The objective of this study is to evaluate the association of Survivin expression with LIHC on the basis of race and gender. Methods: In silico analysis was conducted using information from UACLAN: A portal for facilitating tumor subgroup gene expression and survival analyses. UACLAN uses the data from The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC). Results: Analysis showed a significant relationship between high Survivin expression and lower survival probability with Asian patients than those with tumors that expressed low/medium levels of Survivin. No significant relationship in survival probability was found when comparing Survivin expression among African Americans and Caucasians. There was also a significant relationship shown between low/medium and high Survivin expression in females and lower survival probability than in men with high and low/medium expression, respectively. Lastly, a significant relationship between expression of high levels of Survivin and lower survival probability than in men whose tumors expressed low/medium levels of Survivin was shown. Conclusion: Given the significance of Survivin's expression with survival probability in Asians and gender, Survivin is a promising prognostic biomarker and target for improving the prognosis or treatment of LIHC patients. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12503/30481 | |
| dc.language.iso | en | |
| dc.title | Association of Survivin in Liver Hepatocellular Carcinoma Patient Survival with an Emphasis on Race and Gender | |
| dc.type | poster | |
| dc.type.material | text |