Therapeutic Approaches in the Combat of Pneumococcal Infection

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dc.contributor.advisorJones, Harlan P.
dc.contributor.committeeMemberSu, Dong-Ming
dc.creatorBurnley, Brittney N.
dc.date.accessioned2024-01-18T21:19:03Z
dc.date.available2024-01-18T21:19:03Z
dc.date.issued2017-05
dc.description.abstractPneumonia cause by Streptococcus pneumoniae (S. pneumoniae) is prominent in the young and elderly. Our focus is improving prevention and controlling inflammatory responses during S. pneumoniae infection. Using a mouse model, studies tested the efficacy of nasal administration of a nanoparticle-based (NP) vaccine formulation to improve protection against S. pneumoniae. Studies also sought to determine the effect of nasal administration of corticotropin releasing hormone (CRH). Results demonstrated that CRH administration decreased mortality compared to Dexamethasone. CRH's effect was associated with significant decrease in inflammatory responses and its protective effect was observed in the absence of neutrophils. A NP based vaccine decreased bacterial growth in lungs correlating with increased IFNγ production. This research suggests efficacious applications of prevention and treatment of pneumococcal disease.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32454
dc.language.isoen
dc.subjectS. Pneumoniae
dc.subjectpneumococcal infection
dc.subjectCRH
dc.subjectnanoparticles
dc.subject.meshStreptococcus pneumoniae
dc.subject.meshNanovaccines
dc.subject.meshCorticotropin-Releasing Hormone
dc.titleTherapeutic Approaches in the Combat of Pneumococcal Infection
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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