Chronic Disease, sleep quality, and TNF-alpha: Understanding Pathophysiologic Processes

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2009-08-01

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Sprawls, Kelly S.

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Abstract

The purpose of this study was to explore the association between poor sleep quality and TNF-alpha levels and determine which chronic diseases modify this relationship. In this cross-sectional study of 75 participants, we ascertained sleep quality by means of the Pittsburgh Sleep Quality Index (PSQI). Analyses revealed females were more likely to experience poor sleep quality compared to males. Although sleep quality was not associated with TNFlevels, significant associations were detected with dyslipidemia and tobacco use. Interestingly, we discovered hypertension and diabetes modified the relationship, creating a trend toward inverse associations. As for the relationship between chronic disease and sleep quality, depressive symptomatology and pain were strongly correlated. Unexpectedly, diabetes bordered associations with improved sleep quality. Larger longitudinal studies are needed to confirm these relationships and explore the effects of improved sleep quality and chronic disease management on TNF-alpha levels.

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