Retrospective Analysis of Phase 4 Clinical Trial to Evaluate the Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension

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2021-05

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Lombard, Diandra

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Abstract

One of the biggest challenges patients with rare diseases face is the availability of safe and effective treatment options. Patients with symptomatic neurogenic orthostatic hypotension have a very limited number of pharmacological treatment options available, none of which are approved by the FDA for long term use. This study reviewed preliminary data from a single site in a nationwide clinical trial testing the long-term effectiveness of Droxidopa in patients with symptomatic neurogenic orthostatic hypotension. Long-term effectiveness was measured using two different patient reported surveys completed at various time points in the study. This data was analyzed using a linear regression as well as other descriptive statistics like mean, median, mode and range to assess the effectiveness of Droxidopa over time.

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