Clinical Internship with the Pediatric Clinic's Clinical Research at the Patient Care Center of the University of North Texas Health Science Center/Texas College of Osteopathic Medicine: Literature Review of Meningococcal Meningitis

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dc.contributor.advisorHarold Sheedlo
dc.contributor.committeeMemberRobin Newman
dc.contributor.committeeMemberJohn Fling
dc.creatorPuckett, Fredric Clark
dc.date.accessioned2019-08-22T21:04:04Z
dc.date.available2019-08-22T21:04:04Z
dc.date.issued2002-07-01
dc.date.submitted2014-03-19T06:24:05-07:00
dc.description.abstractEpidemic meningococcal meningitis and meningococcemia disease is caused by the bacterial pathogen Neisseria meningitidis. Once infected with meningococci, onset of the disease is rapid with a high rate or morbidity and mortality. Without medical intervention the mortality rate is over 50%. Medical treatment is over 50%. Medical treatment of an outbreak of the disease with antibiotics can reduce the death rate to 10-15%. However, 10-20% of survivors will suffer from neurological damage that may include loss of hearing, paralysis or mental retardation. Recent concerns have been noted regarding the emergence of Neisseria meningitidis strains resistant to antibiotics. Vaccines have been developed in an effort to reduce epidemic outbreaks of meningococcal meningitis and meningococcemia. The first generation polysaccharide vaccines have shown to be safe and possess some degree of effectiveness but have shortcomings of limited length of immune protection and evidence of hyporesponsiveness to subsequent vaccinations. The second generation conjugated polysaccharide vaccines have been able to overcome these problems and show great promise in reducing the sale of epidemic meningococcal outbreaks with implementation of effective mass vaccination campaigns. In addition, reducing the number of infections will limit the exposure of Neisseria meningitidis to antibiotics and, in theory, slow the development of resistance to antibiotics.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29042
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCells
dc.subjectClinical Epidemiology
dc.subjectHealth Services Research
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectNervous System Diseases
dc.subjectNeuroscience and Neurobiology
dc.subjectOther Pharmacy and Pharmaceutical Sciences
dc.subjectOther Public Health
dc.subjectPharmacy and Pharmaceutical Sciences
dc.subjectPublic Health
dc.subjectEpidemic
dc.subjectmeningococcal meningitis
dc.subjectmeningococcemia disease
dc.subjectbacterial pathogen
dc.subjectNeisseria meningitidis
dc.subjectmeningococci
dc.subjectmortality
dc.subjectmedical treatment
dc.subjectneurological damage
dc.subjectvaccines
dc.subjectantibiotics
dc.subjectclinical internship
dc.titleClinical Internship with the Pediatric Clinic's Clinical Research at the Patient Care Center of the University of North Texas Health Science Center/Texas College of Osteopathic Medicine: Literature Review of Meningococcal Meningitis
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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