Characterization of IL-17A-Secreting CD8 T Cells

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dc.contributor.advisorHarlan Jones
dc.contributor.committeeMemberPorunellor Mathew
dc.contributor.committeeMemberPeter Koulen
dc.creatorLee, Suheung
dc.date.accessioned2019-08-22T21:18:14Z
dc.date.available2019-08-22T21:18:14Z
dc.date.issued2008-12-01
dc.date.submitted2014-02-24T14:54:05-08:00
dc.description.abstractIL-17A-secreting CD4 T cells (Th17 cells) have been demonstrated to play pivotal roles in modulating immune responses during various types to infectious and autoimmune diseases. While 1L-17A secreting CD8 T cells have been detected in numerous disease models, much less is known about them. In this thesis, the differentiation conditions and effector functions of IL-17A-secreting CD8 T cells have been examined. In order to differentiate naïve CD8 T cells into IL-17A secretors, TGF-β, IL-6, and neutralization of IFN-γ are required as in Th17 cells. IL-17A-secreting CD8 T cells produce the effector cytokines, IL-17A, IL-17F and IL-22, but do not produce granzyme B, implicating the lack of cytotoxicity. Furthermore, IL-17A-secreting CD8 T cells can respond to exogenous cytokines without a cognate antigen, suggesting that they can act in an innate fashion. Collectively, IL-17A-secreting CD8 T cells possess the same effector functions as Th17 cells, and thus may play as significant roles in various diseases at Th17 cells.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29229
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedicine and Health Sciences
dc.subjectOther Cell and Developmental Biology
dc.subjectIL-17A
dc.subjectCD4 T Cells
dc.subjectTh17 cells
dc.subjectCD8 T cells
dc.subjectTGF-β
dc.subjectIL-6
dc.subjectneutralization of IFN-γ
dc.subjectIL-17F
dc.subjectIL-22
dc.subjectgranzyme B
dc.subjectcytotoxicity
dc.titleCharacterization of IL-17A-Secreting CD8 T Cells
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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