Modulation of GABAA Receptor Function by Tyrosine Phosphorylation

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dc.contributor.advisorGlenn Dillon
dc.contributor.committeeMemberThomas Yorio
dc.contributor.committeeMemberEugene E. Quist
dc.creatorFang, Mingjun
dc.date.accessioned2019-08-22T21:26:35Z
dc.date.available2019-08-22T21:26:35Z
dc.date.issued1998-05-01
dc.date.submitted2014-01-14T06:24:04-08:00
dc.description.abstractMingjun, Fang. Modulation of GABAA Receptor Function by Tyrosine Phosphorylation. Master of Science (Biomedical Sciences), May, 1998, 32 pp., 6 illustrations, bibliography, 42 titles. The goal of this study was to determine the modulation of GABAA receptor function by tyrosine kinase phosphorylation, and to detect which subunit is phosphorylated to alter the GABA-induced chloride currents. From previous studies, we suggested that protein tyrosine phosphorylation may maintain GABAA receptor function. Here we tested the hypothesis that tyrosine phosphorylation modulates other GABAA receptor subtypes e.g., α1β2γ2 and α6β2γ2, and subsequently attempted to determine which subunit(s) may be phosphorylated. Our results support the hypothesis that PTK phosphorylation may maintain GABAA receptor function. In addition, we suggest this tyrosine phosphorylation occurs at the γ2 subunit of the receptor.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29336
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCellular and Molecular Physiology
dc.subjectChemical Actions and Uses
dc.subjectChemicals and Drugs
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectNervous System
dc.subjectNeuroscience and Neurobiology
dc.subjectOther Neuroscience and Neurobiology
dc.subjectOther Physiology
dc.subjectPhysiology
dc.subjectTissues
dc.subjectModulation
dc.subjectGABAA receptor function
dc.subjecttyrosine kinase phosphorylation
dc.subjectchloride currents
dc.subjectγ2 subunit
dc.titleModulation of GABAA Receptor Function by Tyrosine Phosphorylation
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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