PREPARATION OF A CISPLATIN PRODRUG FOR USE AGAINST NON-SMALL CELL LUNG CANCER
| dc.creator | Redfearn, Warren | |
| dc.creator | Shi, Yi | |
| dc.creator | Koneru, Bhuvaneswari | |
| dc.creator | Di Pasqua, Anthony | |
| dc.date.accessioned | 2019-08-22T19:45:46Z | |
| dc.date.available | 2019-08-22T19:45:46Z | |
| dc.date.issued | 2014-03 | |
| dc.date.submitted | 2014-02-04T14:44:56-08:00 | |
| dc.description.abstract | Background: Lung cancer is the leading cause of cancer-related death in the United States, and non-small cell lung cancer (NSCLC) the most common type. NSCLC is extremely difficult to treat, resulting in a poor prognosis for patients. Platinum (Pt) anti-cancer agents, such as cisplatin, remain a mainstay in the clinic; however, these Pt complexes act nonspecifically, and thus result in serious side-effects. Development and delivery of a Pt complex with an improved therapeutic index would be highly advantageous to the fight against NSCLC. We prepared trans, cis, cis-bis(heptanoato)amine(cyclohexylamine)dichloridoplatinum(IV), referred to here as PtC, and studied its DNA binding and toxicity toward normal lung and NSCLC cells. Methods: A lipophilic Pt(IV) complex, PtC, was synthesized and characterized, and its binding to DNA and toxicity toward various cancer and normal cell lines determined. Results: We confirmed that the synthesized Pt complex binds to DNA in a manner similar to that of cisplatin, which suggests that it is cisplatin prodrug; however, probably due to its lipophilic nature and improved stability, PtC is much more toxic toward NSCLC cell lines than is cisplatin, and has a much improved therapeutic index. Conclusions: PtC shows promise as a therapeutic agent against NSCLC, and, furthermore, its lipophilic nature allows for us to incorporate it into mesoporous silica nanoparticles for fine-controlled release and the targeting of tumors. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12503/26932 | |
| dc.language.iso | en | |
| dc.subject | cisplatin | |
| dc.subject | NSCLC | |
| dc.subject | cancer | |
| dc.title | PREPARATION OF A CISPLATIN PRODRUG FOR USE AGAINST NON-SMALL CELL LUNG CANCER | |
| dc.type | poster | |
| dc.type.material | text |