BEHCET'S DISEASE MANAGED WITH ANTI-FUNGAL

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2013-04-12

Authors

White, Justin

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Abstract

Purpose: The purpose of this case presentation is to highlight the effectiveness of Diflucan medication in the treatment of Behcet's disease; specifically noting the benefit as a adjunct to typical corticosteroids. This will promote future studies into the additional properties and uses of anti-fungal medications. It will also provide another "off label" management option for Behcet's disease. Methods: This was a retrospective chart review of a single case. The materials used included progress notes from primary physicians and consults, lab work, and radiology readings. Results: This patient showed significant symptomatic relief while taking anti-fungal or classic corticosteroid treatments. However, the best subjective relief was following segments of dual treatment with Diflucan and corticosteroids. Further research into Diflucan's properties suggested a inhibition of P-450 liver enzyme thus increasing systemic corticosteroid levels. Conclusions: After studying Diflucan's pharmacological properties and effects on P-450, combined with this particular case presentation, we conclude that Diflucan has potential to be an excellent adjunct medication to use with corticosteroids specifically for Behcet's disease. We also concluded that further research could be done into systemic anti-fungal medication as a adjunct therapy with steroids for any autoimmune disease.

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