Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment

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dc.creatorVintimilla, Raul
dc.creatorBalasubramanian, Kishore
dc.creatorHall, James R.
dc.creatorJohnson, Leigh A.
dc.creatorO'Bryant, Sid E.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.creator.orcid0000-0002-4176-0001 (Vintimilla, Raul)
dc.date.accessioned2022-07-07T13:54:27Z
dc.date.available2022-07-07T13:54:27Z
dc.date.issued2020-11-16
dc.description.abstractObjectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50-86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. Results: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. Conclusions: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia.
dc.description.sponsorshipResearch reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG054073. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. R.V. is also supported by award number RO1AG054073-02S1 Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans - Diversity Supplement.
dc.identifier.citationVintimilla, R., Balasubramanian, K., Hall, J., Johnson, L., & O'Bryant, S. (2020). Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment. Dementia and geriatric cognitive disorders extra, 10(3), 154-162. https://doi.org/10.1159/000511103
dc.identifier.issn1664-5464
dc.identifier.issue3
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31543
dc.identifier.volume10
dc.publisherS. Karger AG
dc.relation.urihttps://doi.org/10.1159/000511103
dc.rights.holderCopyright © 2020 by S. Karger AG, Basel
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceDementia Geriatric Cognitive Disorders Extra
dc.subjectcardiovascular risk factors
dc.subjectmild cognitive impairment
dc.subject.meshHeart Disease Risk Factors
dc.subject.meshCognitive Dysfunction
dc.subject.meshMexican Americans
dc.titleCardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment
dc.typeArticle
dc.type.materialtext

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